共 22 条
Adenovirus-mediated NMDA receptor knockouts in the rat hippocampal CA1 region
被引:7
作者:

Kammesheidt, A
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h-index: 0
机构:
UNIV CALIF IRVINE,DEPT PSYCHOBIOL,IRVINE,CA 92697 UNIV CALIF IRVINE,DEPT PSYCHOBIOL,IRVINE,CA 92697

Kato, K
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h-index: 0
机构:
UNIV CALIF IRVINE,DEPT PSYCHOBIOL,IRVINE,CA 92697 UNIV CALIF IRVINE,DEPT PSYCHOBIOL,IRVINE,CA 92697

Ito, K
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h-index: 0
机构:
UNIV CALIF IRVINE,DEPT PSYCHOBIOL,IRVINE,CA 92697 UNIV CALIF IRVINE,DEPT PSYCHOBIOL,IRVINE,CA 92697

Sumikawa, K
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV CALIF IRVINE,DEPT PSYCHOBIOL,IRVINE,CA 92697 UNIV CALIF IRVINE,DEPT PSYCHOBIOL,IRVINE,CA 92697
机构:
[1] UNIV CALIF IRVINE,DEPT PSYCHOBIOL,IRVINE,CA 92697
来源:
关键词:
adenovirus;
antisense;
in vivo;
N-methyl-D-aspartate;
rat;
D O I:
10.1097/00001756-199702100-00011
中图分类号:
Q189 [神经科学];
学科分类号:
071006 ;
摘要:
ADENOVIRAL antisense constructs of the rat N-methyl-D-aspartate (NMDA) receptor subunit 1 (R1) were assessed for creating NMDAR1 knockouts in rat hippocampal CA1 regions in vivo. In situ hybridization analyses showed that virus-derived antisense transcripts were detected up to 5 weeks postinfection (p.i.). Although immunological methods failed to demonstrate a reduction of NMDA receptor protein, whole-cell recording showed that neurons in the transduced regions were deficient in NMDA receptor-mediated synaptic currents, but not alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor (AMPAR)-mediated synaptic currents. Thus, the data suggest that adenovirus technology can be used to locally knockout specific gene function for dissecting molecular mechanisms of synaptic plasticity.
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收藏
页码:635 / 638
页数:4
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