Muscle strength and bone in healthy women: effect of age and gonadal status

被引:20
作者
Cipriani, Cristiana [1 ]
Romagnoli, Elisabetta [1 ]
Carnevale, Vincenzo [2 ]
Raso, Ida [1 ]
Scarpiello, Addolorata [1 ]
Angelozzi, Maurizio [1 ]
Tancredi, Andrea [3 ]
Russo, Stefania [1 ]
De Lucia, Federica [1 ]
Pepe, Jessica [1 ]
Minisola, Salvatore [1 ]
机构
[1] Univ Roma La Sapienza, Dept Internal Med & Med Disciplines, I-00161 Rome, Italy
[2] Carattere Sci Casa Sollievo Sofferenza Hosp, Ist Ric & Cura, Unit Internal Med, San Giovanni Rotondo, Italy
[3] Univ Roma La Sapienza, Dept Methods & Models Econ Terr & Finance, I-00161 Rome, Italy
来源
HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM | 2012年 / 11卷 / 03期
关键词
Age; Bone; Menopause; Muscle; Strength; MINERAL DENSITY; HANDGRIP STRENGTH; SKELETAL-MUSCLE; POSTMENOPAUSAL WOMEN; GRIP STRENGTH; MASS; SARCOPENIA; ASSOCIATION; OSTEOPOROSIS; EXERCISE;
D O I
10.14310/horm.2002.1361
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE: The aim of this work was to examine the effects of age and menopause on muscle strength and on the muscle-bone interaction. DESIGN: One hundred ninety-four healthy women (mean age 49.8 +/- 12.6 SD years) were assessed. Maximal Voluntary Contraction (MVC, Newton, N) by Hand Grip Dynamometer, bone mineral density at one third of the radius (R-BMD) by dual-energy X-ray absorptiometry (DXA) and phalangeal ultrasound by the DBM Sonic 1200 device were evaluated at the upper dominant limb. Ultrasonometric parameters considered were Amplitude-Dependent Speed of Sound (ADSoS) and Ultrasound Bone Profile Index (UBPI). RESULTS: MVC significantly decreased with age (r(2) = -0.12, p < 0.005). For each level of age, fertile women had a greater MVC compared to postmenopausal women (r(2) = 0.015, p < 0.005). In the whole sample, a statistically significant correlation between MVC and R-BMD (r = 0.354, p < 0.001) and between MVC and ADSoS (r = 0.294) and UBPI (r = 0.311)(p < 0.001 for both) were observed. CONCLUSIONS: We conclude that age and menopausal status significantly contributed to the reduction of muscle strength. The decline of muscular strength significantly correlated with quantitative and qualitative bone features.
引用
收藏
页码:325 / 332
页数:8
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