Kimura disease: review of the literature

被引：101

作者：

Sun, Q. -F. ^{[1
]}

Xu, D. -Z. ^{[5
]}

Pan, S. -H. ^{[2
]}

Ding, J. -G. ^{[1
]}

Xue, Z. -Q. ^{[3
]}

Miao, C. -S. ^{[3
]}

Cao, G. -J. ^{[4
]}

Jin, D. -J. ^{[1
]}

机构：

[1] Third Affiliated Hosp, Wenzhou Med Coll, Dept Infect Dis, Wenzhou, Zhejiang, Peoples R China

[2] Third Affiliated Hosp, Wenzhou Med Coll, Dept Pathol, Wenzhou, Zhejiang, Peoples R China

[3] Third Affiliated Hosp, Wenzhou Med Coll, Dept Nephrol, Wenzhou, Zhejiang, Peoples R China

[4] Third Affiliated Hosp, Wenzhou Med Coll, Dept Surg, Wenzhou, Zhejiang, Peoples R China

[5] Beijing Di Tan Hosp, Beijing, Peoples R China

来源：

INTERNAL MEDICINE JOURNAL | 2008年 / 38卷 / 08期

关键词：

Kimura disease; eosinophilia; immunohistochemistry; protein-tyrosine kinase; Imatinib;

D O I：

10.1111/j.1445-5994.2008.01711.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Kimura disease (KD) is a rare, chronic inflammatory disease of unknown cause and is characterized by painless s.c. swellings and lymphadenopathy commonly affecting the head and neck region. Much therapeutics has been used to treat KD, but is not satisfactory because of frequent relapse. Imatinib has been reported previously to be useful for treatment of hypereosinophilic syndrome and may work by selectively blocking protein-tyrosine kinases, such as platelet-derived growth factor receptor, and c-Kit. We carried out immunohistochemical examination of platelet-derived growth factor receptor-alpha and c-Kit in tissues from patients with KD. The results were positive and suggested that Imatinib might be an effective drug for the treatment of the disease. We have also briefly reviewed the epidemiology, aetiology, clinical manifestations, laboratory and pathological examinations, differential diagnoses, treatment and prognosis of KD in this manuscript.

引用

页码：668 / U5

页数：5