A CELL-BASED ASSAY FOR SCREENING COMPOUNDS THAT AFFECT BRAIN ENDOTHELIAL TIGHT JUNCTION PROTEIN STABILITY; IMPLICATIONS FOR BLOOD-BRAIN BARRIER REPAIR IN TBI

被引：0
|
作者：
Ramirez, Servio H. [1 ]
Fan, Shongshan [1 ]
Dykstra, Holly [1 ]
机构：
[1] Temple Univ, Sch Med, Philadelphia, PA 19122 USA
来源：
JOURNAL OF NEUROTRAUMA | 2012年 / 29卷 / 10期
关键词：
BBB; neuroinflammation; cerebrovascular; permeability; GSK3; beta;
D O I：
暂无
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
引用
收藏
页码：A158 / A159
页数：2
相关论文
共 50 条
  • [41] Current overview of induced pluripotent stem cell-based blood-brain barrier-on-a-chip
    Alves, Arielly da Hora
    Nucci, Mariana Penteado
    do Valle, Nicole Mastandrea Ennes
    Missina, Juliana Morais
    Mamani, Javier Bustamante
    Rego, Gabriel Nery Albuquerque
    Dias, Olivia Furiama Metropolo
    Garrigos, Murilo Montenegro
    de Oliveira, Fernando Anselmo
    Gamarra, Lionel Fernel
    WORLD JOURNAL OF STEM CELLS, 2023, 15 (06): : 632 - 653
  • [42] PFAS & Pesticides effect on cell Survival, Permeability and Tight Junction in an in-vitro model of the Human Blood-Brain Barrier
    Deepika, D.
    Capodiferro, M.
    Esplugas, R.
    Blanco, J.
    Sharma, R. P.
    Schuhmacher, M.
    Grimalt, J.
    Kumar, V.
    TOXICOLOGY LETTERS, 2021, 350 : S91 - S91
  • [43] Highly cationic cell-penetrating peptides affect the barrier integrity and facilitates mannitol permeation in a human stem cell-based blood-brain barrier model
    Froslev, Patrick
    Franzyk, Henrik
    Ozgur, Burak
    Brodin, Birger
    Kristensen, Mie
    EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2022, 168
  • [44] Induced pluripotent stem cell-based endothelial cell models of the human blood-brain barrier to screen gene and other therapies for CNS entry
    Selvakumaran, J.
    Ursu, S.
    Bowerman, M.
    Wood, M.
    Yanez-Munoz, R. J.
    HUMAN GENE THERAPY, 2018, 29 (12) : A85 - A85
  • [45] Effects of HIV-1 Tat and morphine exposure on tight junction RNA and protein expression in a blood-brain barrier model
    Maubert, M. E.
    Strazza, M.
    Pirrone, V
    Lin, W.
    Feng, R.
    Wigdahl, B.
    Nonnemacher, M. R.
    JOURNAL OF NEUROIMMUNE PHARMACOLOGY, 2014, 9 (01) : 35 - 35
  • [46] Effects of selective hypothermia on blood-brain barrier integrity and tight junction protein expression levels after intracerebral hemorrhage in rats
    Sun, Hongwei
    Tang, Ying
    Guan, Xiqin
    Li, Lanfeng
    Wang, Desheng
    BIOLOGICAL CHEMISTRY, 2013, 394 (10) : 1317 - 1324
  • [47] Zika virus E protein modulates functions of human brain microvascular endothelial cells and astrocytes: implications on blood-brain barrier properties
    Kaur, Guneet
    Pant, Pallavi
    Bhagat, Reshma
    Seth, Pankaj
    FRONTIERS IN CELLULAR NEUROSCIENCE, 2023, 17
  • [48] Human Immortalized Cell-Based Blood-Brain Barrier Spheroid Models Offer an Evaluation Tool for the Brain Penetration Properties of Macromolecules
    Kitamura, Keita
    Okamoto, Ayaka
    Morio, Hanae
    Isogai, Ryuto
    Ito, Ryo
    Yamaura, Yoshiyuki
    Izumi, Saki
    Komori, Takafumi
    Ito, Shingo
    Ohtsuki, Sumio
    Akita, Hidetaka
    Furihata, Tomomi
    MOLECULAR PHARMACEUTICS, 2022, 19 (08) : 2754 - 2764
  • [49] Paracellular Barrier and Tight Junction Protein Expression in the Immortalized Brain Endothelial Cell Lines bEND.3, bEND.5 and Mouse Brain Endothelial Cell 4
    Watanabe, Takuya
    Dohgu, Shinya
    Takata, Fuyuko
    Nishioku, Tsuyoshi
    Nakashima, Akio
    Futagami, Koujiro
    Yamauchi, Atsushi
    Kataoka, Yasufumi
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2013, 36 (03) : 492 - 495
  • [50] Comparison of brain capillary endothelial cell-based and epithelial (MDCK-MDR1, Caco-2, and VB-Caco-2) cell-based surrogate blood-brain barrier penetration models
    Hellinger, Eve
    Veszelka, Szilvia
    Toth, Andrea E.
    Walter, Fruzsina
    Kittel, Agnes
    Bakk, Monika Laura
    Tihanyi, Karoly
    Hada, Viktor
    Nakagawa, Shinsuke
    Thuy Dinh Ha Duy
    Niwa, Masami
    Deli, Maria A.
    Vastag, Monika
    EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2012, 82 (02) : 340 - 351
12345