A CELL-BASED ASSAY FOR SCREENING COMPOUNDS THAT AFFECT BRAIN ENDOTHELIAL TIGHT JUNCTION PROTEIN STABILITY; IMPLICATIONS FOR BLOOD-BRAIN BARRIER REPAIR IN TBI

被引:0
|
作者
Ramirez, Servio H. [1 ]
Fan, Shongshan [1 ]
Dykstra, Holly [1 ]
机构
[1] Temple Univ, Sch Med, Philadelphia, PA 19122 USA
关键词
BBB; neuroinflammation; cerebrovascular; permeability; GSK3; beta;
D O I
暂无
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
引用
收藏
页码:A158 / A159
页数:2
相关论文
共 50 条
  • [1] TIGHT JUNCTION COMPLEX MODIFICATION AT THE BLOOD-BRAIN BARRIER IN TBI
    Rom, Slava
    Elliot, Melanie
    Tang, Waixing
    Ramirez, Servio
    JOURNAL OF NEUROTRAUMA, 2011, 28 (06) : A72 - A72
  • [2] Dehydroepiandrosterone sulfate augments blood-brain barrier and tight junction protein expression in brain endothelial cells
    Papadopoulos, Dimitrios
    Scheiner-Bobis, Georgios
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2017, 1864 (08): : 1382 - 1392
  • [3] Correlation of tight junction morphology with the expression of tight junction proteins in blood-brain barrier endothelial cells
    Liebner, S
    Kniesel, U
    Kalbacher, H
    Wolburg, H
    EUROPEAN JOURNAL OF CELL BIOLOGY, 2000, 79 (10) : 707 - 717
  • [4] Cell-based models of blood-brain barrier penetration
    Vastag, Monika
    Hellinger, Eva
    Bakk, Monika L.
    Tihanyi, Karoly
    THERAPEUTIC DELIVERY, 2011, 2 (05) : 549 - 553
  • [5] Differential Involvement of Tight Junction Associated Proteins in Regulating Blood-Brain Barrier Endothelial Cell Permeability
    Tharakan, Binu
    Sawant, Devendra
    Hunter, Felicia A.
    Childs, Ed W.
    FASEB JOURNAL, 2012, 26
  • [6] The epithelial membrane protein 1 is a novel tight junction protein of the blood-brain barrier
    Bangsow, Thorsten
    Baumann, Ewa
    Bangsow, Carmen
    Jaeger, Martina H.
    Pelzer, Bernhard
    Gruhn, Petra
    Wolf, Sabine
    von Melchner, Harald
    Stanimirovic, Danica B.
    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2008, 28 (06): : 1249 - 1260
  • [7] Disruption of blood-brain barrier: effects of HIV Tat on brain microvascular endothelial cells and tight junction proteins
    Sun, Yuqing
    Cai, Miaotian
    Liang, Ying
    Zhang, Yulin
    JOURNAL OF NEUROVIROLOGY, 2023, 29 (06) : 658 - 668
  • [8] EMP-induced alterations of tight junction protein expression and disruption of the blood-brain barrier
    Ding, Gui-Rong
    Qiu, Lian-Bo
    Wang, Xiao-Wu
    Li, Kang-Chu
    Zhou, Yong-Chun
    Zhou, Yan
    Zhang, Jie
    Zhou, Jia-Xing
    Li, Yu-Rong
    Guo, Guo-Zhen
    TOXICOLOGY LETTERS, 2010, 196 (03) : 154 - 160
  • [9] Establishment of a cell-based assay system to screen compounds modulating tight junction barrier.
    Watari, A.
    Kondoh, M.
    Yagi, K.
    MOLECULAR BIOLOGY OF THE CELL, 2011, 22
  • [10] Volatile Anesthetics Influence Blood-Brain Barrier Integrity by Modulation of Tight Junction Protein Expression in Traumatic Brain Injury
    Thal, Serge C.
    Luh, Clara
    Schaible, Eva-Verena
    Timaru-Kast, Ralph
    Hedrich, Jana
    Luhmann, Heiko J.
    Engelhard, Kristin
    Zehendner, Christoph M.
    PLOS ONE, 2012, 7 (12):