BioCycle study: design of the longitudinal study of the oxidative stress and hormone variation during the menstrual cycle

被引:111
作者
Wactawski-Wende, Jean [1 ,2 ]
Schisterman, Enrique F. [4 ]
Hovey, Kathleen M. [1 ]
Howards, Penelope P. [4 ]
Browne, Richard W. [3 ]
Hediger, Mary [4 ]
Liu, Aiyi [4 ]
Trevisan, Maurizio [1 ]
机构
[1] SUNY Buffalo, Dept Social & Prevent Med, Sch Publ Hlth & Hlth Profess, Buffalo, NY 14214 USA
[2] SUNY Buffalo, Dept Gynecol & Obstet, Sch Med & Biomed Sci, Buffalo, NY 14214 USA
[3] SUNY Buffalo, Dept Clin Sci Lab, Sch Med & Biomed Sci, Buffalo, NY 14214 USA
[4] NICHD, Epidemiol Branch, Div Epidemiol Stat & Prevent Res, NIH, Bethesda, MD USA
关键词
menstrual cycle; sex hormones; antioxidants; BioCycle study; study design; oxidative stress; LIPID-PEROXIDATION; ENDOMETRIOSIS; POPULATIONS; BIOMARKERS; MARKERS; DISEASE; PHASE; WOMEN; SERUM;
D O I
10.1111/j.1365-3016.2008.00985.x
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Studies in both human and animal species have suggested that oxidative stress may be associated with health outcomes, including the risk of infertility in both males and females. Sex hormones have been shown to have antioxidant properties. The difficulty in studying the role of oxidative stress in females is partly due to fluctuation in these endogenous sex hormones across the menstrual cycle. The aim of this study was to determine the association of oxidative stress levels with endogenous reproductive hormone levels and antioxidants, including vitamin levels, across the menstrual cycle in a prospective cohort of premenopausal women. The goal was to enrol 250 healthy, regularly menstruating premenopausal women for two menstrual cycles. Participants visited the clinic up to 8 times per cycle, at which time blood and urine were collected. The visits occurred at key hormonally defined phases of the menstrual cycle, with the help of an algorithm based on cycle length and data from a fertility monitor. In addition, participants were administered standardised questionnaires, had various physical measures taken, and had other pertinent data collected. A total of 259 women were enrolled in this study, with 250 completing two cycles, despite a demanding study protocol which participants were required to follow. This report describes the study design, baseline characteristics and visit completion rate for the BioCycle study.
引用
收藏
页码:171 / 184
页数:14
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