Effect of statins on preventing infectious complications after surgery: Systematic review and meta-analysis

被引:6
|
作者
Ma, Bao-Xin [1 ]
Li, Hua [1 ]
Li, Jing-Sen [1 ]
Wu, Sui-Sheng [2 ]
机构
[1] Binzhou Med Univ, Affiliated Hosp, Dept Cardiol, Binzhou, Peoples R China
[2] Jilin Univ, Hosp 1, Dept Geriatr, Changchun 130023, Peoples R China
关键词
Statin; postoperative infection; surgery; CARDIAC-SURGERY; NOSOCOMIAL INFECTIONS; REDUCTASE INHIBITORS; THERAPY; CHOLESTEROL; ASSOCIATION; ANTIOXIDANT; MECHANISM; IMPACT;
D O I
10.1177/0300060515583708
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Objective A meta-analysis to investigate the association between preoperative statin use and the risk of postoperative infectious complications in patients undergoing surgery. Methods PubMed (R) and Embase (R) databases were searched for relevant studies. Data were extracted using a standardized data collection form. The primary effect measure was the odds ratio (OR) of postoperative infectious complications. Summary OR were calculated. Results The analysis included 10 cohort studies with a total of 147263 participants. Statin use was associated with a lower incidence of postoperative infectious complications in all studies (summary OR 0.917, 95% confidence intervals [CI] 0.862, 0.975, fixed-effects model; summary OR 0.731, 95% CI 0.584, 0.870, random-effects model); cardiac surgery (summary OR 0.673; 95% CI 0.535, 0.847); treatment in the USA (summary OR 0.678; 95% CI 0.597, 0.770); retrospective cohort studies (summary OR 0.664; 95% CI 0.521, 0.846). Conclusion Preoperative statin use is associated with a reduced risk of postoperative infectious complications.
引用
收藏
页码:610 / 618
页数:9
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