Human gut microbiota: the links with dementia development

被引：218
作者：
Alkasir, Rashad [1 ]
Li, Jing [1 ]
Li, Xudong [2 ]
Jin, Miao [2 ]
Zhu, Baoli [1 ,3 ]
机构：
[1] Chinese Acad Sci, Inst Microbiol, Beijing 100101, Peoples R China
[2] China Japan Friendship Hosp, Beijing 100029, Peoples R China
[3] Zhejiang Univ, Attainted Hosp 1, Collaborat Innovat Ctr Diag & Treatment Infect Di, Coll Med, Hangzhou 310058, Zhejiang, Peoples R China
来源：
PROTEIN & CELL | 2017年 / 8卷 / 02期
基金：
中国国家自然科学基金;
关键词：
dementia; alzheimer's disease; gut microbiota; inflammation; probiotics; INNATE IMMUNE-RESPONSES; ALZHEIMERS-DISEASE; RISK-FACTORS; INTESTINAL MICROBIOTA; GASTROINTESTINAL-TRACT; INFLAMMATORY MARKERS; PARKINSONS-DISEASE; MOLECULAR ANALYSIS; FECAL MICROFLORA; BACTERIA;
D O I：
10.1007/s13238-016-0338-6
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Dementia is a comprehensive category of brain diseases that is great enough to affect a person's daily functioning. The most common type of dementia is Alzheimer's disease, which makes most of cases. New researches indicate that gastrointestinal tract microbiota are directly linked to dementia pathogenesis through triggering metabolic diseases and low-grade inflammation progress. A novel strategy is proposed for the management of these disorders and as an adjuvant for psychiatric treatment of dementia and other related diseases through modulation of the microbiota (e.g. with the use of probiotics).
引用
收藏
页码：90 / 102
页数：13
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