4(3H)-Quinazolinone derivatives: Promising antibacterial drug leads

被引：163
作者：
Gatadi, Srikanth [1 ]
Lakshmi, T. Vasanta [1 ]
Nanduri, Srinivas [1 ]
机构：
[1] Natl Inst Pharmaceut Educ & Res NIPER, Dept Med Chem, Hyderabad 500037, Telangana, India
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2019年 / 170卷
关键词：
4(3H)-Quinazolinone; Drug resistance; Antibacterial agents; Staphylococcus aureus; Minimum inhibitory concentration; Cytotoxicity; BETA-LACTAM ANTIBIOTICS; ANTIMICROBIAL RESISTANCE; QUINAZOLINONE DERIVATIVES; BIOLOGICAL EVALUATION; MOLECULAR DOCKING; ANTIFUNGAL; AGENTS; CEFTOBIPROLE; CEFTAROLINE; VANCOMYCIN;
D O I：
10.1016/j.ejmech.2019.03.018
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Emergence of drug resistance has created unmet medical need for the development of new classes of antibiotics. Discovery of new antibacterial agents with new mode of action remains a high priority universally. 4(3H)-quinazolinone, a fused nitrogen heterocyclic compound has emerged as a biologically privileged structure, possessing a wide range of biological properties viz, anticancer, antibacterial, antitubercular, antifungal, anti-HIV, anticonvulsant, anti-inflammatory and analgesic activities. Promising antibacterial properties of quinazolinones have enthused the medicinal chemists to explore and develop this fused heterocyclic system for new antibacterial agents. Utilization of quinazolinone core for the design and synthesis of new antibacterial agents has recently gained momentum. This review aims to provide an overview of the structures and antibacterial activity of various 4(3H)-quinazolinone derivatives covering various aspects of in vitro and in vivo pharmacological activities and structure activity relationships (SARs). (C) 2019 Elsevier Masson SAS. All rights reserved.
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页码：157 / 172
页数：16
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