Mannose-conjugated curcumin-chitosan nanoparticles: Efficacy and toxicity assessments against Leishmania donovani

被引：62

作者：

Chaubey, Pramila ^{[1
,2
]}

Mishra, Brahmeshwar ^{[1
]}

Mudavath, Shyam Lal ^{[3
,4
]}

Patel, Ravi R. ^{[1
,5
]}

Chaurasia, Sundeep ^{[1
,6
]}

Sundar, Shyam ^{[3
]}

Suvarna, Vasanti ^{[2
]}

Monteiro, Marvis ^{[2
]}

机构：

[1] Banaras Hindu Univ, Indian Inst Technol, Dept Pharmaceut, Varanasi 221005, Uttar Pradesh, India

[2] SVKMs Dr Bhanuben Nanavati Coll Pharm, Dept Pharmaceut, Mithibai Coll Campus, Bombay, Maharashtra, India

[3] Banaras Hindu Univ, Inst Med Sci, Dept Med, Infect Dis Res Lab, Varanasi 221005, Uttar Pradesh, India

[4] INST, Habitat Ctr, Phase 10,Sect 64, Mohali 160062, Punjab, India

[5] Sun Pharmaceut Adv Res Co, Vadodara, Gujarat, India

[6] Virchow Biotech P Ltd, Survey 172,Part Cagillapur 5, Hyderabad, Andhra Prades, India

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2018年 / 111卷

关键词：

Curcumin; Mannose-conjugated chitosan; Nanoparticles; Macrophages; Visceral leishmaniasis; I CLINICAL-TRIAL; DELIVERY; SYSTEMS; BIOAVAILABILITY; OLIGONUCLEOTIDE; MACROPHAGES; CHITIN;

D O I：

10.1016/j.ijbiomac.2017.12.143

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aim was to fabricate and optimize CUR-loaded mannose-functionalized chitosan nanoparticles (Cur-MCN) which overcome the limitations of drugs to reach the intracellular locations and to establish its therapeutic potential in visceral leishmaniasis by targeting of CUR to macrophages. Cur-MCN were developed by mannose-conjugated chitosan and have been tested for their efficacy and toxicit. In vivo antileishmanial activity in hamsters has shown significantly greater suppression of parasite replication in the spleen with Cur-MCN than unconjugated chitosan nanoparticles. The in vitro cytotoxicity study against the J774A.1 cell line demonstrated its comparative non-toxicity towards the macrophage cells. The potential of Cur-MCN was also confirmed by minimal observed cytotoxicity in our in vivo studies. (C) 2018 Elsevier B.V. All rights reserved.

引用

页码：109 / 120

页数：12

共 40 条

[1] Bioavailability of curcumin: Problems and promises [J].