New potential biologically active compounds:: Design and an efficient synthesis of N-substituted 4-aryl-4,6,7,8-tetrahydroquinoline-2,5(1H,3H)-diones under microwave irradiation

被引：57

作者：

Tu, SJ ^{[1
]}

Zhu, XT ^{[1
]}

Zhang, JP ^{[1
]}

Xu, JN ^{[1
]}

Zhang, Y ^{[1
]}

Wang, Q ^{[1
]}

Jia, RH ^{[1
]}

Jiang, B ^{[1
]}

Zhang, JY ^{[1
]}

Yao, CS ^{[1
]}

机构：

[1] Xuzhou Normal Univ, Dept Chem, Key Lab Biotechnol Med Plant, Xuzhou 221009, Jiangsu, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 11期

基金：

中国国家自然科学基金;

关键词：

quinolone; microwave irradiation; potential biologically active; biomedical screening;

D O I：

10.1016/j.bmcl.2006.03.011

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of N-substituted 4-aryl-4,6,7,8-tetrahydroquinoline-2,5(1H,3H)-diones were synthesized through a rapid one-pot four-component reaction under microwave irradiation. The method has the advantages of excellent yields (82-96%) and short reaction time (4-9 min). We provide new series of potential biologically active compounds for biomedical screening. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：2925 / 2928

页数：4

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