New potential biologically active compounds:: Design and an efficient synthesis of N-substituted 4-aryl-4,6,7,8-tetrahydroquinoline-2,5(1H,3H)-diones under microwave irradiation

被引：57

作者：

Tu, SJ ^{[1
]}

Zhu, XT ^{[1
]}

Zhang, JP ^{[1
]}

Xu, JN ^{[1
]}

Zhang, Y ^{[1
]}

Wang, Q ^{[1
]}

Jia, RH ^{[1
]}

Jiang, B ^{[1
]}

Zhang, JY ^{[1
]}

Yao, CS ^{[1
]}

机构：

[1] Xuzhou Normal Univ, Dept Chem, Key Lab Biotechnol Med Plant, Xuzhou 221009, Jiangsu, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 11期

基金：

中国国家自然科学基金;

关键词：

quinolone; microwave irradiation; potential biologically active; biomedical screening;

D O I：

10.1016/j.bmcl.2006.03.011

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of N-substituted 4-aryl-4,6,7,8-tetrahydroquinoline-2,5(1H,3H)-diones were synthesized through a rapid one-pot four-component reaction under microwave irradiation. The method has the advantages of excellent yields (82-96%) and short reaction time (4-9 min). We provide new series of potential biologically active compounds for biomedical screening. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：2925 / 2928

页数：4

共 27 条

[1]

Abd El-Nabi HA, 1997, PHARMAZIE, V52, P28

[2]

AFONSO A, 1995, Patent No. 6251

[3] Multiple-component condensation strategies for combinatorial library synthesis [J].

Armstrong, RW ;

Combs, AP ;

Tempest, PA ;

Brown, SD ;

Keating, TA .

ACCOUNTS OF CHEMICAL RESEARCH, 1996, 29 (03) :123-131

[4]

Bienaymé H, 2000, CHEM-EUR J, V6, P3321, DOI 10.1002/1521-3765(20000915)6:18<3321::AID-CHEM3321>3.0.CO

[5]

2-A

[6]

Bose AK, 1997, CHEMTECH, V27, P18

[7] Inhibition of autoimmune disease by the immunomodulator linomide correlates with the ability to activate macrophages [J].

Dahlén, E ;

Andersson, M ;

Dawe, K ;

Tellander, AC ;

Brunmark, C ;

Björk, A ;

Hedlund, G .

AUTOIMMUNITY, 2000, 32 (03) :199-211

[8]

DOHERTY TB, 2002, Patent No. 0258695

[9]

Dömling A, 2000, ANGEW CHEM INT EDIT, V39, P3168, DOI 10.1002/1521-3773(20000915)39:18<3168::AID-ANIE3168>3.0.CO

[10]

2-U

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