Impairment of short term memory in rats with hepatic encephalopathy due to bile duct ligation

被引：23

作者：

Leke, Renata ^{[1
,2
]}

Oliveira, Diogo L. ^{[3
]}

Forgiarini, Luiz F. ^{[1
]}

Escobar, Thayssa D. C. ^{[1
]}

Hammes, Thais O. ^{[1
]}

Meyer, Fabiola S. ^{[1
]}

Keiding, Susanne ^{[5
,6
]}

Silveira, Themis R. ^{[1
,2
]}

Schousboe, Arne ^{[4
]}

机构：

[1] Hosp Clin Porto Alegre, Res Ctr, Expt Hepatol & Gastroenterol Lab, BR-90035903 Porto Alegre, RS, Brazil

[2] Univ Fed Rio Grande do Sul, Porto Alegre, RS, Brazil

[3] Univ Fed Rio Grande do Sul, Dept Biochem, BR-90035006 Porto Alegre, RS, Brazil

[4] Univ Copenhagen, Dept Drug Design & Pharmacol, DK-2100 Copenhagen, Denmark

[5] Aarhus Univ Hosp, Positron Emiss Tomog Ctr, DK-8000 Aarhus, Denmark

[6] Aarhus Univ Hosp, Dept Med Hepatol & Gastroenterol 5, DK-8000 Aarhus, Denmark

来源：

METABOLIC BRAIN DISEASE | 2013年 / 28卷 / 02期

关键词：

Hepatic encephalopathy; Bile duct-ligated rats; Short term memory; Long term memory; Object recognition; OBJECT-RECOGNITION MEMORY; RESTORES LEARNING-ABILITY; CHRONIC LIVER-FAILURE; EXPERIMENTAL-MODELS; GABAERGIC TONE; PORTACAVAL SHUNTS; GABA; BRAIN; HYPERAMMONEMIA; MECHANISMS;

D O I：

10.1007/s11011-012-9347-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hepatic encephalopathy (HE) arises from acute or chronic liver diseases and leads to cognitive deficits. Different animal models for the study of HE have demonstrated learning and memory impairment and a number of neurotransmitter systems have been proposed to be involved in this. Recently, it was described that bile duct-ligated (BDL) rats exhibited altered spatio-temporal locomotor and exploratory activities and biosynthesis of neurotransmitter GABA in brain cortices. Therefore, the aim of this study was to evaluate cognition in the same animal model. Male adult Wistar rats underwent common bile duct ligation (BDL rats) or manipulation of common bile duct without ligation (control rats). Six weeks after surgery, control and BDL rats underwent object recognition behavioral task. The BDL rats developed chronic liver failure and exhibited a decreased discrimination index for short term memory (STM) when compared to the control group. There was no difference in long term memory (LTM) as well as in total time of exploration in the training, STM and LTM sessions between the BDL and control rats. Therefore, the BDL rats demonstrated impaired STM for recognition memory, which was not due to decreased exploration.

引用

页码：187 / 192

页数：6

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