Palladium-Catalyzed C-C Triple Bond Cleavage: Efficient Synthesis of 4H-Benzo[d][1,3]oxazin-4-ones

被引：86
作者：
Liu, Qilun [1 ]
Chen, Pinhong [1 ,2 ]
Liu, Guosheng [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
[2] Jiangxi Normal Univ, Key Lab Funct Small Organ Mol, Minist Educ, Nanchang 330022, Peoples R China
来源：
ACS CATALYSIS | 2013年 / 3卷 / 02期
基金：
美国国家科学基金会;
关键词：
Pd catalyst; azidoalkyne; aminocyclization; C-C triple bond cleavage; oxidation; LIPASE INHIBITOR; AMINOFLUORINATION; COMPLEXES; ALKYNE; TRANSFORMATION; CETILISTAT; ACCESS;
D O I：
10.1021/cs300733s
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Described herein is a new transformation of azidoalkynes by using a palladium catalyst, which involves a tandem process of aminopalladation of the alkyne and oxidative rearrangement. The reaction affords a variety of 4H-benzo[d][1,3]oxazin-4-ones. Mechanism studies support a Pd-catalyzed aminopalladation/oxidation/Baeyer-Villiger fragmentary sequence.
引用
收藏
页码：178 / 181
页数：4
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