Advanced precancerous lesions in the liver

被引：72

作者：

Di Tommaso, Luca ^{[1
,2
,3
]}

Sangiovanni, Angelo ^{[4
]}

Borzio, Mauro ^{[5
]}

Park, Young Nyun ^{[6
]}

Farinati, Fabio ^{[7
]}

Roncalli, Massimo ^{[1
,2
,3
]}

机构：

[1] Univ Milan, Dept Med Biotechnol & Translat Med, I-20089 Milan, Italy

[2] Univ Milan, Unit Pathol, I-20089 Milan, Italy

[3] Humanitas Clin & Res Ctr, I-20089 Milan, Italy

[4] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Div Gastroenterol 1, I-20122 Milan, Italy

[5] AO Melegnano, UOC Gastroenterol, Milan, Italy

[6] Yonsei Univ, Coll Med, Dept Pathol, Seoul, South Korea

[7] Univ Padua, Dept Surg Oncol & Gastroenterol, Univ Hosp, I-35128 Padua, Italy

来源：

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY | 2013年 / 27卷 / 02期

关键词：

Early and progressed hepatocellular carcinoma; High grade dysplastic nodule; Radiological and pathological diagnosis; Prognosis and treatment; Diagnostic and prognostic markers; SMALL HEPATOCELLULAR-CARCINOMA; GRADE DYSPLASTIC NODULES; RADIOFREQUENCY ABLATION; PROSPECTIVE VALIDATION; GLUTAMINE-SYNTHETASE; COMPUTED-TOMOGRAPHY; TUMOR-MARKERS; DIAGNOSIS; ACCURACY; IMPACT;

D O I：

10.1016/j.bpg.2013.03.015

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

We will focus on precursors of the most common liver cancer, i.e. hepatocellular carcinoma (HCC), which takes place in 90% of cases in a hepatitis/cirrhotic setting. High grade dysplastic nodules (HG-DN) are small sizable nodules and the most advanced precancerous lesions of the liver, with a risk of malignant transformation of about 30-40% at 24 months. We will survey the diagnostic distinction between them and early HCC from a clinical, radiological and pathological point of view. The use of a diagnostic algorithm supported by international guidelines is the best practice to manage HG-DN and early HCC. There is no typical imaging for HG-DN, needing all of them to be biopsied for characterization. The natural history of HG-DN is not predictable in individual cases and additional markers should be validated to increase the diagnostic accuracy and predict the behaviour. The treatment of HG-DN is under investigation. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：269 / 284

页数：16

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