Metronidazole resistance in Helicobacter pylori

被引：89
作者：
Jenks, PJ
Edwards, DI
机构：
[1] Univ Nottingham Hosp, Queens Med Ctr, Inst Infect & Immunity, Nottingham NG7 2UH, England
[2] Univ E London, Chemotherapy Res Unit, London E15 4LZ, England
来源：
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2002年 / 19卷 / 01期
基金：
英国惠康基金;
关键词：
Helicobacter pylori; metronidazole; resistance; reductase; susceptibility testing;
D O I：
10.1016/S0924-8579(01)00468-X
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Modern triple drug regimens are highly effective for treating Helicobacter pylori infection, but bacterial resistance to one of the most effective antibiotics, metronidazole, is a serious and increasing problem. The activity of metronidazole in H. pylori is dependent on reduction of its nitro moiety to highly reactive compounds that cause DNA strand breakage. The acquisition of resistance is highly associated with. mutational inactivation of the rdxA gene, which encodes an oxygen-insensitive NADPH nitroreductase. Recent evidence has suggested that inactivation of frxA (NADPH flavin oxidoreductase), fdxB (ferredoxin-like protein) and possibly other reductase-encoding genes may also contribute to the resistant phenotype. Improved understanding of the mechanisms of metronidazole resistance in H. pylori is essential for the development and validation of biopsy-based tests for detection of resistance in clinical practice. (C) 2002 Elsevier Science B.V. and the International Society of Chemotherapy. All rights reserved.
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页码：1 / 7
页数：7
相关论文
共 70 条
[1]  
Bilardi C, 2000, GUT, V47, pA2
[2]   Helicobacter pylori uptake and efflux:: Basis for intrinsic susceptibility to antibiotics in vitro [J].
Bina, JE ;
Alm, RA ;
Uria-Nickelsen, M ;
Thomas, SR ;
Trust, TJ ;
Hancock, REW .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (02) :248-254
[3]  
Blaser M J, 1993, Trends Microbiol, V1, P255, DOI 10.1016/0966-842X(93)90047-U
[4]   Metronidazole resistance reduces efficacy of triple therapy and leads to secondary clarithromycin resistance [J].
Buckley, MJM ;
Xia, HX ;
Hyde, DM ;
Keane, CT ;
OMorain, CA .
DIGESTIVE DISEASES AND SCIENCES, 1997, 42 (10) :2111-2115
[5]   PROPOSED MECHANISM FOR METRONIDAZOLE RESISTANCE IN HELICOBACTER-PYLORI [J].
CEDERBRANT, G ;
KAHLMETER, G ;
LJUNGH, A .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1992, 29 (02) :115-120
[6]   Isolation of a genetic locus associated with metronidazole resistance in Helicobacter pylori [J].
Chang, KC ;
Ho, SW ;
Yang, JC ;
Wang, JT .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 236 (03) :785-788
[7]   METRONIDAZOLE AND CANCER [J].
DANIELSON, DA ;
HANNAN, MT ;
JICK, H .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1982, 247 (18) :2498-2499
[8]   Insertion of mini-IS605 and deletion of adjacent sequences in the nitroreductase (rdxA) gene cause metronidazole resistance in Helicobacter pylori NCTC11637 [J].
Debets-Ossenkopp, YJ ;
Pot, RGJ ;
van Westerloo, DJ ;
Goodwin, A ;
Vandenbroucke-Grauls, CMJE ;
Berg, DE ;
Hoffman, PS ;
Kusters, JG .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (11) :2657-2662
[9]  
DOCAMPO R, 1986, FED PROC, V45, P2471
[10]   Effect of pretreatment antibiotic resistance to metronidazole and clarithromycin on outcome of Helicobacter pylori therapy -: A meta-analytical approach [J].
Dore, MP ;
Leandro, G ;
Realdi, G ;
Sepulveda, AR ;
Graham, DY .
DIGESTIVE DISEASES AND SCIENCES, 2000, 45 (01) :68-76
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