Obstructive sleep apnea and nocturnal hypoxemia in adult patients with cystic fibrosis

被引：7

作者：

Welsner, Matthias ^{[1
]}

Dietz-Terjung, Sarah ^{[2
]}

Stehling, Florian ^{[3
]}

Schulte, Tim ^{[2
]}

Niehammer, Ute ^{[1
]}

Gahbiche, Fatma-Ezzahra ^{[1
]}

Taube, Christian ^{[1
,2
]}

Strassburg, Svenja ^{[1
]}

Schoebel, Christoph ^{[2
]}

Weinreich, Gerhard ^{[1
]}

Sutharsan, Sivagurunathan ^{[1
]}

机构：

[1] Univ Duisburg Essen, Univ Hosp Essen, Adult Cyst Fibrosis Ctr, Dept Pulm Med,Ruhrlandklin, Essen, Germany

[2] Univ Duisburg Essen, Univ Hosp Essen, Dept Sleep & Telemed, Ruhrlandklin, Essen, Germany

[3] Univ Duisburg Essen, Childrens Hosp, Cyst Fibrosis Ctr, Pediat Pulmonol & Sleep Med, Essen, Germany

来源：

BMC PULMONARY MEDICINE | 2022年 / 22卷 / 01期

关键词：

Cystic fibrosis; Adults; Polysomnography; Excessive daytime sleepiness; Apnea-hypopnea index; Obstructive sleep apnea; Nocturnal hypoxemia; QUALITY-OF-LIFE; CHRONIC RHINOSINUSITIS; DAYTIME SLEEPINESS; PULMONARY-DISEASE; CHILDREN; DESATURATION; OXYGEN; ASSOCIATIONS; VENTILATION; PREVALENCE;

D O I：

10.1186/s12890-022-02243-0

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Background Obstructive sleep apnea (OSA), nocturnal hypoxemia and excessive daytime sleepiness (EDS) are common comorbidities in people with cystic fibrosis (pwCF). Most of the data showing this originates from children and adolescents. The aim of this study was to collect data on sleep parameters, EDS and pulmonary function from a large cohort of adult pwCF. Methods Full overnight polysomnography (PSG) was performed. EDS was determined using the Epworth Sleepiness Scale (ESS). Demographic and clinical data (body mass index [BMI], pulmonary function, capillary blood gases) were collected. Results A total of 52 adult pwCF were included (mean age 30.7 +/- 8.0 years, mean percent predicted forced expiratory volume in 1 s [ppFEV(1)] of 52.1 +/- 14.8). Overall AHI was in the normal range (4.5 +/- 4.0/h); 21/52 pwCF (40%) had an apnea-hypopnea index > 5/h. Nocturnal hypoxemia was found in 25% of participants and this was associated with ppFEV(1) (p = 0.014), awake oxygen saturation (SpO(2); p = 0.021) and awake partial pressure of oxygen (pO(2); p = 0.003); there were no significant differences in age, lung function and BMI were found for pwCF with versus without OSA (all p > 0.05). Eight pwCF (15%) had an ESS score > 10 (indicating EDS). OSA was best predicted by awake pO(2) (area under the curve [AUC] 0.66, p = 0.048), while nocturnal hypoxemia was best predicted by ppFEV(1) (AUC 0.74, p = 0.009), awake pO(2) (AUC 0.76, p = 0.006) and awake SpO(2) (AUC 0.71; p = 0.025). Conclusion OSA, nocturnal hypoxemia and EDS were common in adult pwCF, but no strong predictors were identified. Therefore, we suggest regular PSG and ESS scoring in adult pwCF, regardless of disease severity.

引用

页数：12