Preparation and Optical Property of New Fluorescent Nanoparticles

被引：11
作者：
Chong, Hui [1 ]
Zhu, Chunlei [1 ]
Song, Jinzhao [1 ]
Feng, Liheng [1 ]
Yang, Qiong [1 ]
Liu, Libing [1 ]
Lv, Fengting [1 ]
Wang, Shu [1 ]
机构：
[1] Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, Key Lab Organ Solids, Beijing 100190, Peoples R China
来源：
MACROMOLECULAR RAPID COMMUNICATIONS | 2013年 / 34卷 / 09期
关键词：
anticancer; cell migration; fluorescent imaging; light irradiation; nanoparticles; ASSISTED LASER INACTIVATION; EGFP-FUSION PROTEINS; CANCER-CELL INVASION; CONJUGATED POLYELECTROLYTES; CARCINOMA-CELLS; IN-VITRO; METASTASIS; HYALURONAN; CD44; KINASE;
D O I：
10.1002/marc.201200755
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
A new fluorescent nanoparticle (PIOT-HA) is synthesized with cationic polyester (PIOT) and anionic hyaluronic acid (HA) by electrostatic interactions in an aqueous solution. The nanoparticles (NPs) are degradable upon treatments with alkali or hyaluronidase, which exhibits better biological safety and potential application in vitro and in vivo. Through specific interactions between the HA locating on the surfaces of PIOT-HA NPs and the CD44 protein over-expressed on the MDA-MB-231 cancer cell line, PIOT-HA NPs could selectively image the cancer cells. Upon white light irradiation, the PIOT-HA NPs can sensitize oxygen to generate reactive oxygen species (ROS) that inactivate the neighboring CD44 protein, which inhibits the migration of MDA-MB-231 cancer cells.
引用
收藏
页码：736 / 742
页数：7
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