Extension of Chronological Lifespan by ScEcl1 Depends on Mitochondria in Saccharomyces cerevisiae

被引：13

作者：

Azuma, Kenko ^{[2
]}

Ohtsuka, Hokuto ^{[1
]}

Murakami, Hiroshi ^{[3
]}

Aiba, Hirofumi ^{[1
]}

机构：

[1] Nagoya Univ, Grad Sch Pharmaceut Sci, Lab Mol Microbiol, Chikusa Ku, Nagoya, Aichi 4640861, Japan

[2] Nagoya Univ, Grad Sch Bioagr Sci, Lab Mol Microbiol, Chikusa Ku, Nagoya, Aichi 4640861, Japan

[3] Saitama Univ, Grad Sch Sci & Engn, Dept Regulatory Biol, Sakura Ku, Saitama 3388570, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2012年 / 76卷 / 10期

关键词：

chronological lifespan; yeast; Ecl1; mitochondria; respiration; CALORIE RESTRICTION EXTENDS; GENE; IDENTIFICATION;

D O I：

10.1271/bbb.120427

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ecl1, a product of the YGR146C gene in Saccharomyces cerevisiae, was identified as a factor involved in chronological lifespan. In this study we found evidence that the function of Ecl1 in the extension of chronological lifespan is dependent on mitochondrial function. The respiratory activity of cells increased when Ecl1 was overexpressed or cells were grown under calorie restriction, but there was no additive effect of calorie restriction and Ecl1 overexpression on increases in respiratory activity or on the extension of chronological lifespan. Based on these results, we propose that overexpression of Ecl1 has same effect as caloric restriction and that its function also depends on mitochondria, just like caloric restriction.

引用

页码：1938 / 1942

页数：5

共 19 条

[1] Identification and Characterization of an Ecl1-Family Gene in Saccharomyces cerevisiae [J].