Neurosteroids as modulators of neurogenesis and neuronal survival

被引：158
作者：
Charalampopoulos, Ioannis [1 ]
Remboutsika, Eurnorphia [2 ]
Margioris, Andrew N. [3 ]
Gravanis, Achille [1 ]
机构：
[1] Univ Crete, Sch Med, Dept Pharmacol, Iraklion 71003, Greece
[2] Biomed Sci Res Ctr Alexander Fleming, Inst Mol Biol & Genet, Stem Cell Biol Lab, Vari Attica 16672, Greece
[3] Univ Crete, Sch Med, Dept Clin Biochem, Iraklion 71003, Greece
来源：
TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2008年 / 19卷 / 08期
关键词：
D O I：
10.1016/j.tem.2008.07.004
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Neurons and glia in the central nervous system express the necessary enzymes for the synthesis of neurosteroids that are produced in concentrations high enough to exert paracrine effects. Synthesis of brain neurosteroids declines with age, during stressful conditions (including major depression, chronic psychological stress), and in chronic inflammatory and neurodegenerative diseases. Recent reports associate the decrease of brain neurosteroids to neuronal dysfunction and degeneration. This review summarizes the recent findings on how the most studied neurosteroids (dehydroepiandrosterone, pregnenolone and their sulphate esters, progesterone and allopregnanolone) affect neuronal survival, neurite outgrowth and neurogenesis; furthermore, this review discusses potential applications of these neurosteroids in the therapeutic management of neurodegenerative conditions, including that of age-related brain atrophy.
引用
收藏
页码：300 / 307
页数：8
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