Neurosteroids as modulators of neurogenesis and neuronal survival

被引：161

作者：

Charalampopoulos, Ioannis ^{[1
]}

Remboutsika, Eurnorphia ^{[2
]}

Margioris, Andrew N. ^{[3
]}

Gravanis, Achille ^{[1
]}

机构：

[1] Univ Crete, Sch Med, Dept Pharmacol, Iraklion 71003, Greece

[2] Biomed Sci Res Ctr Alexander Fleming, Inst Mol Biol & Genet, Stem Cell Biol Lab, Vari Attica 16672, Greece

[3] Univ Crete, Sch Med, Dept Clin Biochem, Iraklion 71003, Greece

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2008年 / 19卷 / 08期

关键词：

D O I：

10.1016/j.tem.2008.07.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Neurons and glia in the central nervous system express the necessary enzymes for the synthesis of neurosteroids that are produced in concentrations high enough to exert paracrine effects. Synthesis of brain neurosteroids declines with age, during stressful conditions (including major depression, chronic psychological stress), and in chronic inflammatory and neurodegenerative diseases. Recent reports associate the decrease of brain neurosteroids to neuronal dysfunction and degeneration. This review summarizes the recent findings on how the most studied neurosteroids (dehydroepiandrosterone, pregnenolone and their sulphate esters, progesterone and allopregnanolone) affect neuronal survival, neurite outgrowth and neurogenesis; furthermore, this review discusses potential applications of these neurosteroids in the therapeutic management of neurodegenerative conditions, including that of age-related brain atrophy.

引用

页码：300 / 307

页数：8

共 71 条

[1] Neuroprotective strategies for basal ganglia degeneration: Parkinson's and Huntington's diseases [J].

Alexi, T ;

Borlongan, CV ;

Faull, RLM ;

Williams, CE ;

Clark, RG ;

Gluckman, PD ;

Hughes, PE .

PROGRESS IN NEUROBIOLOGY, 2000, 60 (05) :409-470

[2] Pathogenesis in menstrual cycle-linked CNS disorders [J].

Bäckström, T ;

Andersson, A ;

Andreé, L ;

Birzniece, V ;

Bixo, M ;

Björn, I ;

Haage, D ;

Isaksson, M ;

Johansson, IM ;

Lindblad, C ;

Lundgren, P ;

Nyberg, S ;

Ödmark, IS ;

Strömberg, J ;

Sundström-Poromaa, I ;

Turkmen, S ;

Wahlström, G ;

Wang, MD ;

Wohlbäck, AC ;

Zhu, D ;

Zingmark, E .

STEROIDS AND THE NERVOUS SYSTEM, 2003, 1007 :42-53

[3]

Barbaccia Maria Luisa, 2004, Critical Reviews in Neurobiology, V16, P67, DOI 10.1615/CritRevNeurobiol.v16.i12.70

[4] Dehydroepiandrosterone (DHEA) protects hippocampal cells from oxidative stress-induced damage [J].

Bastianetto, S ;

Ramassamy, C ;

Poirier, J ;

Quirion, R .

MOLECULAR BRAIN RESEARCH, 1999, 66 (1-2) :35-41

[5]

Baulieu EE, 2001, INT REV NEUROBIOL, V46, P1

[6] Progesterone as a neuroactive neurosteroid, with special reference to the effect of progesterone on myelination [J].

Baulieu, EE ;

Schumacher, M .

STEROIDS, 2000, 65 (10-11) :605-612

[7] Neuroactive steroids and inhibitory neurotransmission: mechanisms of action and physiological relevance [J].

Belelli, D ;

Herd, MB ;

Mitchell, EA ;

Peden, DR ;

Vardy, AW ;

Gentet, L ;

Lambert, JJ .

NEUROSCIENCE, 2006, 138 (03) :821-829

[8] Neurosteroids:: Endogenous regulators of the GABAA receptor [J].

Belelli, D ;

Lambert, JJ .

NATURE REVIEWS NEUROSCIENCE, 2005, 6 (07) :565-575

[9]

BRINTON RD, 1994, J NEUROSCI, V14, P2763

[10]

Brinton Roberta Diaz, 2006, Current Alzheimer Research, V3, P185

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