Spinal cord stimulation improves forelimb use in an alpha-synuclein animal model of Parkinson's disease

被引：11

作者：

Brys, Ivani ^{[1
,2
]}

Bobela, Wojciech ^{[3
]}

Schneider, Bernard L. ^{[3
]}

Aebischer, Patrick ^{[3
]}

Fuentes, Romulo ^{[2
,4
]}

机构：

[1] Univ Fed Rio Grande do Norte, Dept Psychobiol, Natal, RN, Brazil

[2] Edmond & Lily Safra Inst Neurosci Natal, BR-590660 Natal, RN, Brazil

[3] Ecole Polytech Fed Lausanne, Brain Mind Inst, Lausanne, Switzerland

[4] Univ Chile, Inst Ciencias Biomed, Programa Fisiol & Biofis, Fac Med, Santiago, Chile

来源：

INTERNATIONAL JOURNAL OF NEUROSCIENCE | 2017年 / 127卷 / 01期

关键词：

Parkinson's disease; alpha-synuclein; spinal cord stimulation; DEEP BRAIN-STIMULATION; TARGETED OVEREXPRESSION; NIGROSTRIATAL SYSTEM; SUBTHALAMIC NUCLEUS; DOPAMINE NEURONS; ADULT RATS; VEGF; AGGREGATION; LOCOMOTION; PATHOLOGY;

D O I：

10.3109/00207454.2016.1138296

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neuromodulation by spinal cord stimulation has been proposed as a symptomatic treatment for Parkinson's disease. We tested the chronic effects of spinal cord stimulation in a progressive model of Parkinson's based on overexpression of alpha-synuclein in the substantia nigra. Adult Sprague Dawley rats received unilateral injections of adeno-associated virus serotype 6 (AAV6) in the substantia nigra to express alpha-synuclein. Locomotion and forepaw use of the rats were evaluated during the next 10 weeks. Starting on week 6, a group of AAV6-injected rats received spinal cord stimulation once a week. At the end of the experiment, tyrosine hydroxylase and alpha-synuclein immunostaining were performed. Rats with unilateral alpha-synuclein expression showed a significant decrease in the use of the contralateral forepaw, which was mildly but significantly reverted by spinal cord stimulation applied once a week from the 6th to the 10th week after the AAV6 injection. Long-term spinal cord stimulation proved to be effective to suppress or delay motor symptoms in a sustained and progressive model of Parkinson's and might become an alternative, less invasive neuromodulation option to treat this disease.

引用

页码：28 / 36

页数：9

共 39 条

[1] Spinal Cord Stimulation for the Treatment of Abnormal Posture and Gait Disorder in Patients With Parkinson's Disease [J].

Agari, Takashi ;

Date, Isao .

NEUROLOGIA MEDICO-CHIRURGICA, 2012, 52 (07) :470-474

[2]

Arii Y, 2014, J NEUROL NEUROSURG P

[3] Electrical Stimulation of the Cerebral Cortex Exerts Antiapoptotic, Angiogenic, and Anti-Inflammatory Effects in Ischemic Stroke Rats Through Phosphoinositide 3-Kinase/Akt Signaling Pathway [J].

Baba, Tanefumi ;

Kameda, Masahiro ;

Yasuhara, Takao ;

Morimoto, Takamasa ;

Kondo, Akihiko ;

Shingo, Tetsuro ;

Tajiri, Naoki ;

Wang, Feifei ;

Miyoshi, Yasuyuki ;

Borlongan, Cesario V. ;

Matsumae, Mitsunori ;

Date, Isao .

STROKE, 2009, 40 (11) :E598-E605

[4] Functional electrical stimulation helps replenish progenitor cells in the injured spinal cord of adult rats [J].

Becker, Daniel ;

Gary, Devin S. ;

Rosenzweig, Ephron S. ;

Grill, Warren M. ;

McDonald, John W. .

EXPERIMENTAL NEUROLOGY, 2010, 222 (02) :211-218

[5] Deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson's disease [J].

Benabid, Alim Louis ;

Chabardes, Stephan ;

Mitrofanis, John ;

Pollak, Pierre .

LANCET NEUROLOGY, 2009, 8 (01) :67-81

[6] Rapid alterations in corticostriatal ensemble coordination during acute dopamine-dependent motor dysfunction [J].

Costa, Rui M. ;

Lin, Shih-Chieh ;

Sotnikova, Tatyana D. ;

Cyr, Michel ;

Gainetdinov, Raul R. ;

Caron, Marc G. ;

Nicolelis, Miguel A. L. .

NEURON, 2006, 52 (02) :359-369

[7] PHARMACOLOGICAL AND NONPHARMACOLOGICAL INTERVENTIONS IN THE TREATMENT OF PARKINSONS-DISEASE [J].

CUTSON, TM ;

LAUB, KC ;

SCHENKMAN, M .

PHYSICAL THERAPY, 1995, 75 (05) :363-373

[8] Progressive neurodegenerative and behavioural changes induced by AAV-mediated overexpression of α-synuclein in midbrain dopamine neurons [J].

Decressac, M. ;

Mattsson, B. ;

Lundblad, M. ;

Weikop, P. ;

Bjorklund, A. .

NEUROBIOLOGY OF DISEASE, 2012, 45 (03) :939-953

[9] Targeted overexpression of the parkin substrate Pael-R in the nigrostriatal system of adult rats to model Parkinson's disease [J].

Dusonchet, Julien ;

Bensadoun, Jean-Charles ;

Schneider, Bernard L. ;

Aebischer, Patrick .

NEUROBIOLOGY OF DISEASE, 2009, 35 (01) :32-41

[10] Oscillatory activity in the basal ganglia [J].

Eusebio, Alexandre ;

Brown, Peter .

PARKINSONISM & RELATED DISORDERS, 2007, 13 :S434-S436

← 1 2 3 4 →