Protective effect of curcumin on cypermethrin-induced oxidative stress in Wistar rats

被引：104
作者：
Sankar, Palanisamy [1 ]
Telang, Avinash G. [1 ]
Manimaran, Ayyasamy [1 ]
机构：
[1] Indian Vet Res Inst, Div Pharmacol & Toxicol, Bareilly 243122, Uttar Pradesh, India
来源：
EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY | 2012年 / 64卷 / 05期
关键词：
Cypermethrin; Curcumin; Oxidative stress; Antioxidants; Rats; POSSIBLE INVOLVEMENT; LIPID-PEROXIDATION; VITAMIN-E; DAMAGE; PYRETHROIDS; FENVALERATE; TISSUE; BRAIN; MICE;
D O I：
10.1016/j.etp.2010.11.003
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
The aim of present study was to investigate the protective effect of curcumin on cypermethrin-induced changes in blood biochemical markers and tissue antioxidant enzyme in rats. Rats were divided into six groups of six each: group I used as control and II and III groups were used as vehicle control. While, groups IV, V and VI were orally treated with curcumin (100 mg/kg body weight), cypermethrin (25 mg/kg body weight) and cypermethrin plus curcumin, respectively for 28 days. Serum biochemical markers were measured in the serum, and the levels of lipid peroxidation and antioxidant enzyme activity were determined in the liver, kidney and brain. Cypermethrin administration caused elevated level of blood biochemical markers in serum and lipid peroxidation in liver, kidney and brain. While the activities of non-enzymatic and enzymatic antioxidants levels were decreased except superoxide dismutase in liver, kidney and brain tissues. The presence of curcumin with cypermethrin significantly decreased the blood biochemical markers and lipid peroxidation but significantly increased the reduced glutathione, catalase and glutathione peroxidase level and preserved the normal histological architecture of the liver, kidney and brain. Our results indicate that curcumin can be potent protective agent against cypermethrin-induced biochemical alterations and oxidative damage in rats. (C) 2010 Elsevier GmbH. All rights reserved.
引用
收藏
页码：487 / 493
页数：7
相关论文
共 60 条
  • [1] Adelsbach TL, 2003, REV ENVIRON CONTAM T, V176, P137
  • [2] Aebi H.E., 1983, Methods of enzymatic analysis, P273, DOI DOI 10.1016/J.REPROTOX.2005.05.003
  • [3] Atessahin A, 2005, TURK J VET ANIM SCI, V29, P385
  • [4] Curcumin induces glutathione biosynthesis and inhibits NF-κB activation and interleukin-8 release in alveolar epithelial cells:: Mechanism of free radical scavenging activity
    Biswas, SK
    McClure, D
    Jimenez, LA
    Megson, IL
    Rahman, I
    [J]. ANTIOXIDANTS & REDOX SIGNALING, 2005, 7 (1-2) : 32 - 41
  • [5] ACUTE TOXICITY OF 2 PYRETHROIDS, PERMETHRIN, AND CYPERMETHRIN IN NEONATAL AND ADULT-RATS
    CANTALAMESSA, F
    [J]. ARCHIVES OF TOXICOLOGY, 1993, 67 (07) : 510 - 513
  • [6] Curcumin prevents oxidative renal damage induced by acetaminophen in rats
    Cekmen, M.
    Ilbey, Y. O.
    Ozbek, E.
    Simsek, A.
    Somay, A.
    Ersoz, C.
    [J]. FOOD AND CHEMICAL TOXICOLOGY, 2009, 47 (07) : 1480 - 1484
  • [7] HYDROPEROXIDE METABOLISM IN MAMMALIAN ORGANS
    CHANCE, B
    SIES, H
    BOVERIS, A
    [J]. PHYSIOLOGICAL REVIEWS, 1979, 59 (03) : 527 - 605
  • [8] ANTIOXIDANTS AND LIPID-PEROXIDATION - INVIVO STUDIES
    CORONGIU, FP
    VARGIOLU, S
    MILIA, A
    CHEESEMAN, KH
    SLATER, TF
    [J]. BIOCHEMICAL PHARMACOLOGY, 1985, 34 (03) : 397 - 398
  • [9] Through metal binding, curcumin protects against lead- and cadmium-induced lipid peroxidation in rat brain homogenates and against lead-induced tissue damage in rat brain
    Daniel, S
    Limson, JL
    Dairam, A
    Watkins, GM
    Daya, S
    [J]. JOURNAL OF INORGANIC BIOCHEMISTRY, 2004, 98 (02) : 266 - 275
  • [10] Chemopreventive and therapeutic effects of curcumin
    Duvoix, A
    Blasius, R
    Delhalle, S
    Schnekenburger, M
    Morceau, F
    Henry, E
    Dicato, M
    Diederich, M
    [J]. CANCER LETTERS, 2005, 223 (02) : 181 - 190
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