Spatio-Temporal Regulation of RhoGTPases Signaling by Myosin II

被引：11

作者：

Wu, Selwin K. ^{[1
,2
]}

Priya, Rashmi ^{[3
]}

机构：

[1] Harvard Med Sch, Dept Cell Biol, Boston, MA 02115 USA

[2] Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA

[3] Max Planck Inst Heart & Lung Res, Dept Dev Genet, Bad Nauheim, Germany

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2019年 / 7卷

关键词：

pulsatility; morphogenesis; GTPase signaling; adhesion and migration; active fluid media; actomyosin; E-CADHERIN; ACTIN; CONTRACTILITY; TENSION; ADHESION; PATTERNS; ORCHESTRATE; JUNCTIONS; CORTEX; CELLS;

D O I：

10.3389/fcell.2019.00090

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

RhoGTPase activation of non-muscle myosin II regulates cell division, extrusion, adhesion, migration, and tissue morphogenesis. However, the regulation of myosin II and mechanotransduction is not straightforward. Increasingly, the role of myosin II on the feedback regulation of RhoGTPase signaling is emerging. Indeed, myosin II controls RhoGTPase signaling through multiple mechanisms, namely contractility driven advection, scaffolding, and sequestration of signaling molecules. Here we discuss these mechanisms by which myosin II regulates RhoGTPase signaling in cell adhesion, migration, and tissue morphogenesis.

引用

页数：5

共 38 条

[1] Mammalian Diaphanous 1 Mediates a Pathway for E-cadherin to Stabilize Epithelial Barriers through Junctional Contractility [J].

Acharya, Bipul R. ;

Wu, Selwin K. ;

Lieu, Zi Zhao ;

Parton, Robert G. ;

Grill, Stephan W. ;

Bershadsky, Alexander D. ;

Gomez, Guillermo A. ;

Yap, Alpha S. .

CELL REPORTS, 2017, 18 (12) :2854-2867

[2] Nonmuscle myosin IIA-dependent force inhibits cell spreading and drives F-actin flow [J].

Cai, Yunfei ;

Biais, Nicolas ;

Giannone, Gregory ;

Tanase, Monica ;

Jiang, Guoying ;

Hofman, Jake M. ;

Wiggins, Chris H. ;

Silberzan, Pascal ;

Buguin, Axel ;

Ladoux, Benoit ;

Sheetz, Michael P. .

BIOPHYSICAL JOURNAL, 2006, 91 (10) :3907-3920

[3] Cytoskeletal coherence requires myosin-IIA contractility [J].

Cai, Yunfei ;

Rossier, Olivier ;

Gauthier, Nils C. ;

Biais, Nicolas ;

Fardin, Marc-Antoine ;

Zhang, Xian ;

Miller, Lawrence W. ;

Ladoux, Benoit ;

Cornish, Virginia W. ;

Sheetz, Michael P. .

JOURNAL OF CELL SCIENCE, 2010, 123 (03) :413-423

[4] NF2/Merlin mediates contact-dependent inhibition of EGFR mobility and internalization via cortical actomyosin [J].

Chiasson-MacKenzie, Christine ;

Morris, Zachary S. ;

Baca, Quentin ;

Morris, Breit ;

Coker, Joanna K. ;

Mirchev, Rossen ;

Jensen, Anne E. ;

Carey, Thomas ;

Stott, Shannon L. ;

Golan, David E. ;

McClatchey, Andrea I. .

JOURNAL OF CELL BIOLOGY, 2015, 211 (02) :391-405

[5] Actin and α-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent manner [J].

Choi, Colin K. ;

Vicente-Manzanares, Miguel ;

Zareno, Jessica ;

Whitmore, Leanna A. ;

Mogilner, Alex ;

Horwitz, Alan Rick .

NATURE CELL BIOLOGY, 2008, 10 (09) :1039-U36

[6] Nonmuscle myosin II moves in new directions [J].

Conti, Mary Anne ;

Adelstein, Robert S. .

JOURNAL OF CELL SCIENCE, 2008, 121 (01) :11-18

[7] Myosin IIA regulates cell motility and actomyosin microtubule crosstalk [J].

Even-Ram, Sharona ;

Doyle, Andrew D. ;

Conti, Mary Anne ;

Matsumoto, Kazue ;

Adelstein, Robert S. ;

Yamada, Kenneth M. .

NATURE CELL BIOLOGY, 2007, 9 (03) :299-U104

[8] An RPTPα/Src family kinase/Rap1 signaling module recruits myosin IIB to support contractile tension at apical E-cadherin junctions [J].

Gomez, Guillermo A. ;

McLachlan, Robert W. ;

Wu, Selwin K. ;

Caldwell, Benjamin J. ;

Moussa, Elliott ;

Verma, Suzie ;

Bastiani, Michele ;

Priya, Rashmi ;

Parton, Robert G. ;

Gaus, Katharina ;

Sap, Jan ;

Yap, Alpha S. .

MOLECULAR BIOLOGY OF THE CELL, 2015, 26 (07) :1249-1262

[9] Productive tension: force-sensing and homeostasis of cell-cell junctions [J].

Gomez, Guillermo A. ;

McLachlan, Robert W. ;

Yap, Alpha S. .

TRENDS IN CELL BIOLOGY, 2011, 21 (09) :499-505

[10] Mutations in SIPA1L3 cause eye defects through disruption of cell polarity and cytoskeleton organization [J].

Greenlees, Rebecca ;

Mihelec, Marija ;

Yousoof, Saira ;

Speidel, Daniel ;

Wu, Selwin K. ;

Rinkwitz, Silke ;

Prokudin, Ivan ;

Perveen, Rahat ;

Cheng, Anson ;

Ma, Alan ;

Nash, Benjamin ;

Gillespie, Rachel ;

Loebel, David A. F. ;

Clayton-Smith, Jill ;

Lloyd, I. Christopher ;

Grigg, John R. ;

Tam, Patrick P. L. ;

Yap, Alpha S. ;

Becker, Thomas S. ;

Black, Graeme C. M. ;

Semina, Elena ;

Jamieson, Robyn V. .

HUMAN MOLECULAR GENETICS, 2015, 24 (20) :5789-5804

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