Association between Inflammatory Gene Polymorphisms and the Risk of Myocardial Infarction

被引：7
作者：
Nasibullin, T. R. [1 ]
Sadikova, R. I. [1 ]
Timasheva, Ya. R. [1 ]
Tuktarova, I. A. [1 ]
Erdman, V. V. [1 ]
Khusainova, L. N. [2 ]
Nikolaeva, I. E. [3 ]
Mustafina, O. E. [1 ]
机构：
[1] Russian Acad Sci, Ufa Res Ctr, Inst Biochem & Genet, Ufa 450054, The Republic Of, Russia
[2] Hosp Bashkir State Med Univ, Ufa 450059, Russia
[3] Republican Cardiol Hlth Ctr, Ufa 450106, Russia
来源：
RUSSIAN JOURNAL OF GENETICS | 2014年 / 50卷 / 02期
基金：
俄罗斯基础研究基金会;
关键词：
MONOCYTE CHEMOATTRACTANT PROTEIN-1; CORONARY-HEART-DISEASE; ENDOTHELIAL-CELLS; E-SELECTIN; ATHEROSCLEROSIS; EXPRESSION; GAMMA; K469E; LDL;
D O I：
10.1134/S1022795414020112
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Allele and genotype frequency distributions of polymorphism rs2076059 (3832T>C) within the SELE gene, rs6131 (S290N), within the SELP gene, rs1131498 (F206L), within the SELL gene, rs5498 (K469E) within the ICAM1 gene, rs35569394 (-2549(18)I/D) within the VEGFA gene, and rs1024611 (-2518A>G) within the CCL2 gene were examined in a group of patients after myocardial infarction (MI)(280 individuals) and in a control group (312 individuals). An implementation of the Markov chain and Monte-Carlo method (APSampler) revealed the allele combinations associated with decreased and increased risk of MI. Among these, the most important allele combinations were SELE*C + SELP*S + CCL2*A (FDR = 0.0005; OR = 0.42), SELP*S + CCL2*A (FDR = 0.0009; OR = 0.36), SELL*F + VEGFA*I + CCL2*G/G (FDR = 0.0009; OR = 4.17), VEGFA*I + CCL2*G/G (FDR = 0.0009; OR = 3.76), SELE*C + CCL2*A (FDR = 0.0023; OR = 0.47), and SELL*F + CCL2*G/G (FDR = 0.003; OR = 3.15).
引用
收藏
页码：211 / 217
页数：7
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