Association between Inflammatory Gene Polymorphisms and the Risk of Myocardial Infarction

被引：7

作者：

Nasibullin, T. R. ^{[1
]}

Sadikova, R. I. ^{[1
]}

Timasheva, Ya. R. ^{[1
]}

Tuktarova, I. A. ^{[1
]}

Erdman, V. V. ^{[1
]}

Khusainova, L. N. ^{[2
]}

Nikolaeva, I. E. ^{[3
]}

Mustafina, O. E. ^{[1
]}

机构：

[1] Russian Acad Sci, Ufa Res Ctr, Inst Biochem & Genet, Ufa 450054, The Republic Of, Russia

[2] Hosp Bashkir State Med Univ, Ufa 450059, Russia

[3] Republican Cardiol Hlth Ctr, Ufa 450106, Russia

来源：

RUSSIAN JOURNAL OF GENETICS | 2014年 / 50卷 / 02期

基金：

俄罗斯基础研究基金会;

关键词：

MONOCYTE CHEMOATTRACTANT PROTEIN-1; CORONARY-HEART-DISEASE; ENDOTHELIAL-CELLS; E-SELECTIN; ATHEROSCLEROSIS; EXPRESSION; GAMMA; K469E; LDL;

D O I：

10.1134/S1022795414020112

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Allele and genotype frequency distributions of polymorphism rs2076059 (3832T>C) within the SELE gene, rs6131 (S290N), within the SELP gene, rs1131498 (F206L), within the SELL gene, rs5498 (K469E) within the ICAM1 gene, rs35569394 (-2549(18)I/D) within the VEGFA gene, and rs1024611 (-2518A>G) within the CCL2 gene were examined in a group of patients after myocardial infarction (MI)(280 individuals) and in a control group (312 individuals). An implementation of the Markov chain and Monte-Carlo method (APSampler) revealed the allele combinations associated with decreased and increased risk of MI. Among these, the most important allele combinations were SELE*C + SELP*S + CCL2*A (FDR = 0.0005; OR = 0.42), SELP*S + CCL2*A (FDR = 0.0009; OR = 0.36), SELL*F + VEGFA*I + CCL2*G/G (FDR = 0.0009; OR = 4.17), VEGFA*I + CCL2*G/G (FDR = 0.0009; OR = 3.76), SELE*C + CCL2*A (FDR = 0.0023; OR = 0.47), and SELL*F + CCL2*G/G (FDR = 0.003; OR = 3.15).

引用

页码：211 / 217

页数：7

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