Susceptibility of clinical isolates of Fusarium to antifungal drugs

被引：32

作者：

Speeleveld, E

Gordts, B

VanLanduyt, HW

DeVroey, C

RaesWuytack, C

机构：

[1] ALGEMEEN ZIEKENHUIS ST JAN,DEPT MICROBIOL,B-8000 BRUGGE,BELGIUM

[2] PRINS LEOPOLD INST TROP GENEESKUNDE,DEPT MYCOL,ANTWERP,BELGIUM

来源：

MYCOSES | 1996年 / 39卷 / 1-2期

关键词：

Fusarium; susceptibility tests; antifungal agents; amphotericin B; azoles; terbinafine;

D O I：

10.1111/j.1439-0507.1996.tb00081.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The inhibitory activities of amphotericin B, fluconazole, itraconazole, miconazole, ketoconazole and terbinafine against nine isolates from clinically apparent infections of Fusarium solani, four isolates of Fusarium moniliforme and 10 isolates of Fusarium oxysporum were determined with an agar diffusion method (Neo-sensitabs) and an agar dilution method. The inhibition zones obtained with antifungal Neo-sensitabs need very careful interpretation. We did not find a good correlation between the agar diffusion method using Neo-sensitabs preloaded with azoles and amphotericin B and the agar dilution method. Amphotericin B (12/23) and terbinafine (18/23) showed good activity. Miconazole (7/23) and ketoconazole (3/23) had poor inhibitory activity. Fluconazole and itraconazole (0/23) had no in vitro activity against any of the isolates tested.

引用

页码：37 / 40

页数：4

共 8 条

[1] THE EMERGING ROLE OF FUSARIUM INFECTIONS IN PATIENTS WITH CANCER [J].