Leukemia inhibitory factor (LIF)

被引:386
作者
Nicola, Nicos A. [1 ,2 ]
Babon, Jeffrey J. [1 ,2 ]
机构
[1] Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3052, Australia
[2] Univ Melbourne, Dept Med Biol, Melbourne, Vic 3050, Australia
基金
澳大利亚研究理事会; 英国医学研究理事会; 美国国家卫生研究院;
关键词
Leukemia inhibitory factor; JAK/STAT/SOCS; LIF receptor; Embryonic stem cells; Pregnancy; Nerve and muscle; EMBRYONIC STEM-CELLS; ACTIVATED PROTEIN-KINASE; SKELETAL-MUSCLE REGENERATION; RAT SYMPATHETIC NEURONS; IL-6 SIGNAL TRANSDUCER; PRIMORDIAL GERM-CELLS; SELF-RENEWAL; FACTOR-RECEPTOR; ONCOSTATIN-M; CRYSTAL-STRUCTURE;
D O I
10.1016/j.cytogfr.2015.07.001
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Leukemia inhibitory factor (LIF) is the most pleiotropic member of the interleukin-6 family of cytokines. It utilises a receptor that consists of the LIE receptor beta and gp130 and this receptor complex is also used by ciliary neurotrophic growth factor (CNTF), oncostatin M, cardiotrophinl (CT1) and cardiotrophin-like cytokine (CLC). Despite common signal transduction mechanisms (JAK/STAT, MAPK and PI3K) LIF can have paradoxically opposite effects in different cell types including stimulating or inhibiting each of cell proliferation, differentiation and survival. While LIF can act on a wide range of cell types, LIF knockout mice have revealed that many of these actions are not apparent during ordinary development and that they may be the result of induced LIF expression during tissue damage or injury. Nevertheless LIF does appear to have non-redundant actions in maternal receptivity to blastocyst implantation, placental formation and in the development of the nervous system. LIF has also found practical use in the maintenance of self-renewal and totipotency of embryonic stem cells and induced pluripotent stem cells. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码:533 / 544
页数:12
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