Occupational trichloroethylene hypersensitivity syndrome: Human herpesvirus 6 reactivation and rash phenotypes

被引：30

作者：

Kamijima, Michihiro ^{[1
]}

Wang, Hailan ^{[2
]}

Yamanoshita, Osamu ^{[3
]}

Ito, Yuki ^{[1
]}

Xia, Lihua ^{[2
]}

Yanagiba, Yukie ^{[4
]}

Chen, Cishan ^{[2
]}

Okamura, Ai ^{[5
]}

Huang, Zhenlie ^{[2
]}

Qiu, Xinxiang ^{[2
]}

Song, Xiangrong ^{[2
]}

Cai, Tingfeng ^{[2
]}

Liu, Lili ^{[2
]}

Ge, Yichen ^{[2
]}

Deng, Yingyu ^{[2
]}

Naito, Hisao ^{[5
]}

Yoshikawa, Tetsushi ^{[6
]}

Tohyama, Mikiko ^{[7
]}

Li, Laiyu ^{[2
]}

Huang, Hanlin ^{[2
]}

Nakajima, Tamie ^{[5
]}

机构：

[1] Nagoya City Univ, Grad Sch Med Sci, Dept Occupat & Environm Hlth, Nagoya, Aichi, Japan

[2] Guangdong Prov Hosp Occupat Dis Prevent & Treatme, Guangzhou, Guangdong, Peoples R China

[3] Chubu Univ, Coll Life & Hlth Sci, Dept Biomed Sci, Kasugai, Aichi 487, Japan

[4] Natl Inst Occupat Safety & Hlth, Kawasaki, Kanagawa, Japan

[5] Nagoya Univ, Grad Sch Med, Dept Occupat & Environm Hlth, Nagoya, Aichi 4648601, Japan

[6] Fujita Hlth Univ, Sch Med, Dept Pediat, Toyoake, Aichi 47011, Japan

[7] Ehime Univ, Grad Sch Med, Dept Dermatol, Toon, Japan

来源：

JOURNAL OF DERMATOLOGICAL SCIENCE | 2013年 / 72卷 / 03期

基金：

日本学术振兴会; 日本科学技术振兴机构;

关键词：

Trichloroethylene; Human herpesvirus 6; Reactivation; Drug-induced hypersensitivity syndrome (DIHS); Cytokine; Biomarker; GENERALIZED SKIN DISORDERS; STEM-CELL TRANSPLANTATION; ADVERSE DRUG-REACTIONS; HUMAN-HERPESVIRUS-6; REACTIVATION; EXANTHEM-SUBITUM; SYSTEMIC SYMPTOMS; DERMATITIS; EXPOSURE; WORKERS; SERUM;

D O I：

10.1016/j.jdermsci.2013.07.003

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background: Trichloroethylene (TCE) is an industrial solvent which can cause severe generalized dermatitis, i.e., occupational ICE hypersensitivity syndrome. Reactivation of latent human herpesvirus 6 (HHV6) can occur in such patients, which has made TCE known as a causative chemical of drug-induced hypersensitivity syndrome (DIHS). Objective: This study aimed to clarify HHV6 status, cytokine profiles and their association with rash phenotypes in patients with TCE hypersensitivity syndrome. Methods: HHV6 DNA copy numbers, anti-HHV6 antibody titers, and cytokines were measured in blood prospectively sampled 5-7 times from 28 hospitalized patients with the disease. Results: The patients (19 had exfoliative dermatitis (ED) and 9 had non-ED type rash) generally met the diagnostic criteria for DIHS. Viral reactivation defined as increases in either HHV6 DNA (>= 100 genomic copies/10(6) peripheral blood mononuclear cells) or antibody titers was identified in 24 (89%) patients. HHV6 DNA, tumor necrosis factor (TNF)-alpha, interferon (IFN)-gamma, interleukin (IL)-5, IL-6 and IL-10 concentrations were remarkably higher in the patients than in the healthy workers (p < 0.01). Positive correlations between HHV6 DNA, TNF-alpha, IFN-gamma, IL-6 and IL-10 were significant (p < 0.05) except for that between HHV6 DNA and IFN-gamma. An increase in HHV6 DNA was positively associated with an increase in TNF-alpha on admission (p < 0.01). HHV6 DNA, the antibody titers, TNF-alpha and IL-10 concentrations were significantly higher in ED than in the non-ED type (p < 0.05). Conclusion: Reactivated HHV6 and the increased cytokines could be biomarkers of TCE hypersensitivity syndrome. The higher-level reactivation and stronger humoral responses were associated with ED-type rash. (C) 2013 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved.

引用

页码：218 / 224

页数：7