Selective biosensing using straight long-range surface plasmon waveguides

被引：0

作者：

Krupin, O. ^{[1
]}

Wang, Chen ^{[1
]}

Berini, P. ^{[1
]}

机构：

[1] Univ Ottawa, Dept Biol & Chem Engn, Ottawa, ON, Canada

来源：

PHOTONICS NORTH 2013 | 2013年 / 8915卷

关键词：

Long-range surface plasmon-polariton; cytop; biosensor; human immunoglobulin; MACH-ZEHNDER INTERFEROMETER; RESONANCE SENSORS; SENSITIVITY; FABRICATION; EXCITATION; METALS;

D O I：

10.1117/12.2036362

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

A novel biosensing platform based on long-range surface plasmon waveguides is demonstrated for selective biosensing. The sensor consists of gold waveguides embedded in CYTOP with a microfluidic channel. Gold surfaces were modified by forming a self-assembled monolayer (SAM) and further they were functionalized by proper receptor (antibodies) with carbodiimide chemistry. Investigation of biochemical interactions were performed with human immunoglobulin (Ig). Human immunoglobulin M (IgM) kappa chain (IgM-kappa) was tested on the waveguide, functionalized with anti-human immunoglobulin-kappa specific chain (anti-Ig kappa). As a negative control, human IgM lambda chain (IgM-lambda) was tested on anti-Ig kappa surface. The response for IgM-kappa sample was 0.173 dBm and that for IgM-lambda was 0.033. The ratio of the responses Delta S(IgM-kappa)/ Delta S(IgM-lambda) was found to be 5.3.

引用

页数：7

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