The role of plasma IDO activity as a diagnostic marker of patients with colorectal cancer

被引：21

作者：

Cavia-Saiz, M. ^{[1
]}

Muniz Rodriguez, P. ^{[2
]}

Llorente Ayala, B. ^{[3
]}

Garcia-Gonzalez, M. ^{[4
]}

Coma-del Corral, M. J. ^{[1
]}

Garcia Giron, C. ^{[4
]}

机构：

[1] Univ Hosp Burgos, Res Unit, Burgos, Spain

[2] Univ Burgos, Biochem & Mol Biol Area, Burgos, Spain

[3] Univ Hosp Burgos, Oncol Unit, Burgos, Spain

[4] Univ Hosp Burgos, Oncol Serv, Burgos, Spain

来源：

MOLECULAR BIOLOGY REPORTS | 2014年 / 41卷 / 04期

关键词：

Biomarker; Colorectal cancer; Indoleamine 2,3-dioxygenase; L-Kynurenine; INDOLEAMINE 2,3-DIOXYGENASE EXPRESSION; TUMOR-MARKERS; PROGNOSTIC VALUE; EGTM GUIDELINES; 2,3 DIOXYGENASE; EUROPEAN GROUP; COLON-CANCER; DISEASE; KYNURENINE; PREDICTS;

D O I：

10.1007/s11033-014-3080-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

High levels of indoleamine 2,3-dioxygenase (IDO) are involved in tumour escape mechanisms. The aim of this study is the evaluation of l-kynurenine of plasma as marker of diagnostic and prognostic in patients with colorectal cancer. The study included 78 patients with colorectal cancer, of whom 15 % were in stage I/II, 30 % in stage III, and 55 % in stage IV, and was compared with a control group of 70 healthy subjects. The receiver operating characteristic (ROC) curve analysis showed an area under the curve of 0.917, with a specificity of 100 % and with a sensitivity to detect cancer of the colon of 85.2 %, taking 1.83 mu M as a cut-off point. The overall survival analysis also indicated that patients with low levels of l-kynurenine in plasma increased survival rate after 45 months of follow-up (P = 0.032). These results show that the plasma levels of l-kynurenine could be a good biomarker to differentiate individuals with colorectal cancer from healthy individuals.

引用

页码：2275 / 2279

页数：5

共 29 条

[1] Tryptophan metabolites interfere with the Ehrlich reaction used for the measurement of kynurenine [J].