P(OEt)3-Mediated Formal S-H Insertion: Reductive Couplings of Isatins with Thiols to Generate 3-Sulfenylated Oxindoles

被引：8

作者：

Huang, Tiao ^{[1
]}

Liu, Li ^{[1
]}

Wang, Qinghe ^{[1
]}

Kong, Dulin ^{[2
]}

Wu, Mingshu ^{[1
]}

机构：

[1] Hainan Normal Univ, Key Lab Trop Med Plant Chem, Minist Educ, Coll Chem & Chem Engn, Haikou 571158, Hainan, Peoples R China

[2] Hainan Med Univ, Sch Pharmaceut Sci, Haikou 571199, Hainan, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2020年 / 52卷 / 18期

关键词：

triethyl phosphite; S-H bond insertion; carbenoids; 3-sulfenylation oxindoles; isatins; N-H; O-H; ORGANOCATALYZED SULFENYLATION; ENANTIOSELECTIVE SYNTHESIS; ASYMMETRIC SULFENYLATION; ALPHA-DIKETONES; CARBON; ANTIFUNGAL; QUINONES; ACCESS;

D O I：

10.1055/s-0040-1707147

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new P(OEt)(3)-mediated formal S-H bond-insertion reaction of isatins into thiols for the synthesis of valuable 3-sulfenylation oxindoles has been developed. This approach takes advantage of the unique reactivity of Kukhtin-Ramirez adducts to allow direct reductive S-H functionalization with commercially available and bench-stable starting materials.

引用

页码：2689 / 2697

页数：9

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