Cancer stem cells in osteosarcoma

被引：245
作者：
Brown, Hannah K. [1 ,2 ]
Tellez-Gabriel, Marta [3 ]
Heymann, Dominique [1 ,2 ,4 ]
机构：
[1] Univ Sheffield, Sch Med, Dept Oncol & Metab, Beech Hill Rd, Sheffield S10 2RX, S Yorkshire, England
[2] Univ Sheffield, INSERM, European Associated Lab, Sarcoma Res Unit,Med Sch, Beech Hill Rd, Sheffield S10 2RX, S Yorkshire, England
[3] Hosp Santa Creui St Pau, Inst Invest Biomed IBB St Pau, Lab Hematol Oncol & Transplantes, Barcelona 08025, Spain
[4] Univ Nantes, Fac Med, INSERM,Equipe Ligue 2012, UMR 957,Pathophysiol Bone Resorpt & Therapy Prima, F-44035 Nantes, France
来源：
CANCER LETTERS | 2017年 / 386卷
关键词：
Osteosarcoma; Bone cancer; Cancer stem cell; Tumour heterogeneity; SIDE POPULATION CELLS; DECIPHERING INTRATUMOR HETEROGENEITY; TUMOR-INITIATING CELLS; CD133; EXPRESSION; DRUG-RESISTANCE; BONE SARCOMAS; SELF-RENEWAL; SOLID TUMORS; ACTIVATION; DRIVER;
D O I：
10.1016/j.canlet.2016.11.019
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Osteosarcoma is the most common primary bone tumour in children and adolescents and advanced osteosarcoma patients with evidence of metastasis share a poor prognosis. Osteosarcoma frequently gains resistance to standard therapies highlighting the need for improved treatment regimens and identification of novel therapeutic targets. Cancer stem cells (CSC) represent a sub-type of tumour cells attributed to critical steps in cancer including tumour propagation, therapy resistance, recurrence and in some cases metastasis. Recent published work demonstrates evidence of cancer stem cell phenotypes in osteosarcoma with links to drug resistance and tumorigenesis. In this review we will discuss the commonly used isolation techniques for cancer stem cells in osteosarcoma as well as the identified biochemical and molecular markers. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：189 / 195
页数：7
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