Cancer stem cells in osteosarcoma

被引：235
作者：
Brown, Hannah K. [1 ,2 ]
Tellez-Gabriel, Marta [3 ]
Heymann, Dominique [1 ,2 ,4 ]
机构：
[1] Univ Sheffield, Sch Med, Dept Oncol & Metab, Beech Hill Rd, Sheffield S10 2RX, S Yorkshire, England
[2] Univ Sheffield, INSERM, European Associated Lab, Sarcoma Res Unit,Med Sch, Beech Hill Rd, Sheffield S10 2RX, S Yorkshire, England
[3] Hosp Santa Creui St Pau, Inst Invest Biomed IBB St Pau, Lab Hematol Oncol & Transplantes, Barcelona 08025, Spain
[4] Univ Nantes, Fac Med, INSERM,Equipe Ligue 2012, UMR 957,Pathophysiol Bone Resorpt & Therapy Prima, F-44035 Nantes, France
来源：
CANCER LETTERS | 2017年 / 386卷
关键词：
Osteosarcoma; Bone cancer; Cancer stem cell; Tumour heterogeneity; SIDE POPULATION CELLS; DECIPHERING INTRATUMOR HETEROGENEITY; TUMOR-INITIATING CELLS; CD133; EXPRESSION; DRUG-RESISTANCE; BONE SARCOMAS; SELF-RENEWAL; SOLID TUMORS; ACTIVATION; DRIVER;
D O I：
10.1016/j.canlet.2016.11.019
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Osteosarcoma is the most common primary bone tumour in children and adolescents and advanced osteosarcoma patients with evidence of metastasis share a poor prognosis. Osteosarcoma frequently gains resistance to standard therapies highlighting the need for improved treatment regimens and identification of novel therapeutic targets. Cancer stem cells (CSC) represent a sub-type of tumour cells attributed to critical steps in cancer including tumour propagation, therapy resistance, recurrence and in some cases metastasis. Recent published work demonstrates evidence of cancer stem cell phenotypes in osteosarcoma with links to drug resistance and tumorigenesis. In this review we will discuss the commonly used isolation techniques for cancer stem cells in osteosarcoma as well as the identified biochemical and molecular markers. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：189 / 195
页数：7
相关论文
共 47 条
  • [1] Osteosarcoma: Cells-of-Origin, Cancer Stem Cells, and Targeted Therapies
    Abarrategi, Ander
    Tornin, Juan
    Martinez-Cruzado, Lucia
    Hamilton, Ashley
    Martinez-Campos, Enrique
    Rodrigo, Juan P.
    Victoria Gonzalez, M.
    Baldini, Nicola
    Garcia-Castro, Javier
    Rodriguez, Rene
    [J]. STEM CELLS INTERNATIONAL, 2016, 2016
  • [2] CD117 and Stro-1 Identify Osteosarcoma Tumor-Initiating Cells Associated with Metastasis and Drug Resistance
    Adhikari, Amit S.
    Agarwal, Neeraj
    Wood, Byron M.
    Porretta, Constance
    Ruiz, Bernardo
    Pochampally, Radhika R.
    Iwakuma, Tomoo
    [J]. CANCER RESEARCH, 2010, 70 (11) : 4602 - 4612
  • [3] [Anonymous], ONCOTARGET
  • [4] Sox2 maintains self renewal of tumor-initiating cells in osteosarcomas
    Basu-Roy, U.
    Seo, E.
    Ramanathapuram, L.
    Rapp, T. B.
    Perry, J. A.
    Orkin, S. H.
    Mansukhani, A.
    Basilico, C.
    [J]. ONCOGENE, 2012, 31 (18) : 2270 - 2282
  • [5] Sox2 antagonizes the Hippo pathway to maintain stemness in cancer cells
    Basu-Roy, Upal
    Bayin, N. Sumru
    Rattanakorn, Kirk
    Han, Eugenia
    Placantonakis, Dimitris G.
    Mansukhani, Alka
    Basilico, Claudio
    [J]. NATURE COMMUNICATIONS, 2015, 6
  • [6] Perspectives on cancer stem cells in osteosarcoma
    Basu-Roy, Upal
    Basilico, Claudio
    Mansukhani, Alka
    [J]. CANCER LETTERS, 2013, 338 (01) : 158 - 167
  • [7] Hedgehog signaling induces osteosarcoma development through Yap1 and H19 overexpression
    Chan, L. H.
    Wang, W.
    Yeung, W.
    Deng, Y.
    Yuan, P.
    Mak, K. K.
    [J]. ONCOGENE, 2014, 33 (40) : 4857 - 4866
  • [8] Clarke Michael F, 2006, Cancer Res, V66, P9339, DOI 10.1158/0008-5472.CAN-06-3126
  • [9] Sphere-forming stem-like cell populations with drug resistance in human sarcoma cell lines
    Fujii, Hiromasa
    Honoki, Kanya
    Tsujiuchi, Toshifumi
    Kido, Akira
    Yoshitani, Kazuhiro
    Takakura, Yoshinori
    [J]. INTERNATIONAL JOURNAL OF ONCOLOGY, 2009, 34 (05) : 1381 - 1386
  • [10] Clinical Relevance and Therapeutic Significance of MicroRNA-133a Expression Profiles and Functions in Malignant Osteosarcoma-Initiating Cells
    Fujiwara, Tomohiro
    Katsuda, Takeshi
    Hagiwara, Keitaro
    Kosaka, Nobuyoshi
    Yoshioka, Yusuke
    Takahashi, Ryou-U
    Takeshita, Fumitaka
    Kubota, Daisuke
    Kondo, Tadashi
    Ichikawa, Hitoshi
    Yoshida, Akihiko
    Kobayashi, Eisuke
    Kawai, Akira
    Ozaki, Toshifumi
    Ochiya, Takahiro
    [J]. STEM CELLS, 2014, 32 (04) : 959 - 973
12345