Role of immune sera in the in-vitro phagocytosis of Bordetella pertussis strains

被引：6
作者：
Stefanelli, P
Ippoliti, R
Fazio, C
Mastrantonio, P
机构：
[1] Ist Super Sanita, Dept Bacteriol & Med Mycol, I-00161 Rome, Italy
[2] Univ Aquila, Dept Pure & Appl Biol, I-67100 Laquila, Italy
来源：
MICROBIAL PATHOGENESIS | 2002年 / 32卷 / 03期
关键词：
Bordetella pertussis; opsonophagocytosis; THP-1; cells;
D O I：
10.1006/mpat.2001.0488
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In this study, phagocytosis of Bordetella pertussis was assessed using a human monocyte-derived macrophage line (THP-1) and immune sera from children who had received primary vaccination during the Italian clinical trial on the efficacy of two acellular three-component (PT-FHA-PRN) and one whole-cell pertussis vaccines. The results demonstrate that phagocytosis of opsonized bacteria with specific immune sera is not significantly enhanced compared with that of non-opsonized bacteria or bacteria opsonized with non-immune sera. A similar result was obtained also using B. pertussis strains showing variants of the pertactin antigen suggesting that those variations do not reduce the capability of the bacterium to invade the monocytes. (C) 2002 Elsevier Science Ltd.
引用
收藏
页码：135 / 141
页数：7
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