Facile synthesis, characterization, and evaluation of neurotoxicity effect of cerium oxide nanoparticles

被引:84
作者
Darroudi, Majid [1 ]
Hakimi, Mohammad [2 ]
Sarani, Mina [2 ,3 ]
Oskuee, Reza Kazemi [1 ,4 ]
Zak, Ali Khorsand [5 ]
Gholami, Leila [1 ]
机构
[1] Mashhad Univ Med Sci, Sch Med, Dept Modern Sci & Technol, Mashhad, Iran
[2] Payame Noor Univ, Dept Chem, Tehran 193954697, Iran
[3] Zabol Univ Med Sci, Zabol Med Plants Res Ctr, Zabol, Iran
[4] Mashhad Univ Med Sci, Targeted Drug Delivery Res Ctr, Mashhad, Iran
[5] Ferdowsi Univ Mashhad, Fac Sci, Dept Phys, Electroceram & Mat Lab, Mashhad, Iran
关键词
Sol-gel processes; Electron microscopy; CeO2; SILVER NANOPARTICLES; GREEN SYNTHESIS; GELATIN; CEO2; PRECIPITATION; PARTICLES;
D O I
10.1016/j.ceramint.2013.02.026
中图分类号
TQ174 [陶瓷工业]; TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
Cerium oxide nanoparticles (CeO2-NPs) were synthesized via the sol-gel method in gelatin media. Long-chain gelatin compounds were utilized to terminate the growth of CeO2-NPs and stabilize them. The CeO2-NPs were characterized by a number of techniques, including X-ray diffraction analysis (XRD), UV-vis spectrophotometry, and high-magnification transmission electron microscopy (TEM). The CeO2-NPs calcined at different temperatures exhibited a cubic fluoride structure with sizes less than approximately 10 um. The influence of the calcination temperature on the morphology of CeO2-NPs was also investigated. In vitro cytotoxicity studies on neuro2A cells showed a dose-dependent toxicity with non-toxic effect of concentration below 10 mu g/mL. The results indicated that gelatin is an interesting material that can be used as a stabilizer in the sol gel processes for preparing small CeO2-NPs. (C) 2013 Elsevier Ltd and Techna Group S.r.l. All rights reserved.
引用
收藏
页码:6917 / 6921
页数:5
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