Pulsatile Drug Release from PLGA Hollow Microspheres by Controlling the Permeability of Their Walls with a Magnetic Field

被引：72
作者：
Chiang, Wei-Lun [3 ]
Ke, Cherng-Jyh [3 ]
Liao, Zi-Xian [3 ]
Chen, San-Yuan [4 ]
Chen, Fu-Rong [5 ]
Tsai, Chun-Ying [5 ]
Xia, Younan [1 ,2 ]
Sung, Hsing-Wen [3 ]
机构：
[1] Georgia Inst Technol, Wallace H Coulter Dept Biomed Engn, Atlanta, GA 30332 USA
[2] Emory Univ, Atlanta, GA 30332 USA
[3] Natl Tsing Hua Univ, Dept Chem Engn, Hsinchu 30013, Taiwan
[4] Natl Chiao Tung Univ, Dept Mat Sci & Engn, Hsinchu 30013, Taiwan
[5] Natl Tsing Hua Univ, Dept Engn & Syst Sci, Hsinchu 30013, Taiwan
来源：
SMALL | 2012年 / 8卷 / 23期
关键词：
pulsatile drug release; molecular switches; magnetic stimulus; iron oxide nanoparticles; DELIVERY; DESIGN; SYSTEM; NANOPARTICLES;
D O I：
10.1002/smll.201201743
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Pulsatile release: When a high-frequency magnetic field is applied, heat will be generated by coupling to the iron oxide nanoparticles encapsulated in the shells of PLGA hollow microspheres. As the temperature approaches the T g of PLGA, the polymer chains become more mobile, subsequently increasing the free volume of PLGA matrix and significantly enhancing the diffusion of drug molecules. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：3584 / 3588
页数：5
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