An overview of microRNAs

被引：1121
作者：
Hammond, Scott M. [1 ]
机构：
[1] Univ N Carolina, Lineberger Comprehens Canc Ctr, Dept Cell Biol & Physiol, Chapel Hill, NC 27599 USA
来源：
ADVANCED DRUG DELIVERY REVIEWS | 2015年 / 87卷
关键词：
miRNA; MicroRNA; Dicer; Drosha; Argonaute; RNAi; RNA-BINDING PROTEIN; C VIRUS-RNA; DOUBLE-STRANDED-RNA; MESSENGER-RNA; POSTTRANSCRIPTIONAL REGULATION; NUCLEAR EXPORT; IN-VIVO; CIRCULATING MICRORNAS; WIDE IDENTIFICATION; GENE-EXPRESSION;
D O I：
10.1016/j.addr.2015.05.001
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The discovery of the first microRNA (miRNA) over 20 years ago has ushered in a new era in molecular biology. There are now over 2000 miRNAs that have been discovered in humans and it is believed that they collectively regulate one third of the genes in the genome. miRNAs have been linked to many human diseases and are being pursued as clinical diagnostics and as therapeutic targets. This review presents an overview of the miRNA pathway, including biogenesis routes, biological roles, and clinical approaches. (C) 2015 Elsevier B.V. All rights reserved.
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收藏
页码：3 / 14
页数：12
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