An overview of microRNAs

被引:1121
作者
Hammond, Scott M. [1 ]
机构
[1] Univ N Carolina, Lineberger Comprehens Canc Ctr, Dept Cell Biol & Physiol, Chapel Hill, NC 27599 USA
关键词
miRNA; MicroRNA; Dicer; Drosha; Argonaute; RNAi; RNA-BINDING PROTEIN; C VIRUS-RNA; DOUBLE-STRANDED-RNA; MESSENGER-RNA; POSTTRANSCRIPTIONAL REGULATION; NUCLEAR EXPORT; IN-VIVO; CIRCULATING MICRORNAS; WIDE IDENTIFICATION; GENE-EXPRESSION;
D O I
10.1016/j.addr.2015.05.001
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The discovery of the first microRNA (miRNA) over 20 years ago has ushered in a new era in molecular biology. There are now over 2000 miRNAs that have been discovered in humans and it is believed that they collectively regulate one third of the genes in the genome. miRNAs have been linked to many human diseases and are being pursued as clinical diagnostics and as therapeutic targets. This review presents an overview of the miRNA pathway, including biogenesis routes, biological roles, and clinical approaches. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码:3 / 14
页数:12
相关论文
共 245 条
[1]   Recognition of the let-7g miRNA precursor by human Lin28B [J].
Ali, P. Shaik Syed ;
Ghoshdastider, Umesh ;
Hoffmann, Jan ;
Brutschy, Bernd ;
Filipek, Slawomir .
FEBS LETTERS, 2012, 586 (22) :3986-3990
[2]   Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma [J].
Arroyo, Jason D. ;
Chevillet, John R. ;
Kroh, Evan M. ;
Ruf, Ingrid K. ;
Pritchard, Colin C. ;
Gibson, Donald F. ;
Mitchell, Patrick S. ;
Bennett, Christopher F. ;
Pogosova-Agadjanyan, Era L. ;
Stirewalt, Derek L. ;
Tait, Jonathan F. ;
Tewari, Muneesh .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (12) :5003-5008
[3]   Exosomes in cancer development, metastasis, and drug resistance: a comprehensive review [J].
Azmi, Asfar S. ;
Bao, Bin ;
Sarkar, Fazlul H. .
CANCER AND METASTASIS REVIEWS, 2013, 32 (3-4) :623-642
[4]   Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs [J].
Babiarz, Joshua E. ;
Ruby, J. Graham ;
Wang, Yangming ;
Bartel, David P. ;
Blelloch, Robert .
GENES & DEVELOPMENT, 2008, 22 (20) :2773-2785
[5]  
Bader Andreas G., 2012, Frontiers in Genetics, V3, P120, DOI 10.3389/fgene.2012.00120
[6]   The impact of microRNAs on protein output [J].
Baek, Daehyun ;
Villen, Judit ;
Shin, Chanseok ;
Camargo, Fernando D. ;
Gygi, Steven P. ;
Bartel, David P. .
NATURE, 2008, 455 (7209) :64-U38
[7]   Coupled RNA Processing and Transcription of Intergenic Primary MicroRNAs [J].
Ballarino, Monica ;
Pagano, Francesca ;
Girardi, Erika ;
Morlando, Mariangela ;
Cacchiarelli, Davide ;
Marchioni, Marcella ;
Proudfoot, Nicholas J. ;
Bozzoni, Irene .
MOLECULAR AND CELLULAR BIOLOGY, 2009, 29 (20) :5632-5638
[8]   Beta Cell 5′-Shifted isomiRs Are Candidate Regulatory Hubs in Type 2 Diabetes [J].
Baran-Gale, Jeanette ;
Fannin, Emily E. ;
Kurtz, C. Lisa ;
Sethupathy, Praveen .
PLOS ONE, 2013, 8 (09)
[9]   MicroRNAs and cancer: Profile, profile, profile [J].
Barbarotto, Elisa ;
Schmittgen, Thomas D. ;
Calin, George A. .
INTERNATIONAL JOURNAL OF CANCER, 2008, 122 (05) :969-977
[10]   MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].
Bartel, David P. .
CELL, 2007, 131 (04) :11-29