TXNDC9 Expression in Colorectal Cancer Cells and Its Influence on Colorectal Cancer Prognosis

被引：23

作者：

Lu, Aiguo ^{[1
,3
]}

Wangpu, Xiongzhi ^{[1
]}

Han, Dingpei ^{[1
]}

Feng, Hao ^{[1
]}

Zhao, Jingkun ^{[1
,3
]}

Ma, Junjun ^{[1
]}

Qu, Shun ^{[1
]}

Chen, Xuehua ^{[2
]}

Liu, Bingya ^{[3
]}

Zheng, Minhua ^{[1
]}

机构：

[1] Ruijin Hosp, Shanghai Minimally Invas Surg Ctr, Shanghai, Peoples R China

[2] Laiwu City Peoples Hosp, Dept Gen Surg, Laiwu, Shandong, Peoples R China

[3] Shanghai Jiao Tong Univ, Sch Med, Shanghai Inst Digest Surg, Ruijin Hosp, Shanghai 200030, Peoples R China

来源：

CANCER INVESTIGATION | 2012年 / 30卷 / 10期

关键词：

Colorectal Cancer; Cell Proliferation; Cell Invasion; Cancer Prognosis; PHOSDUCIN; GENE;

D O I：

10.3109/07357907.2012.732160

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this study, we analyzed the protein expression of thioredoxin domain containing 9 (TXNDC9) in 116 colorectal cancer (CRC) cases. Among them, 97 were positive in CRC tissues and 60 were positive in normal mucosa. TXNDC9 expression in CRC was correlated with the extent of tumor invasion and the tumor size. TXNDC9-negative patients had longer lifespans. In vitro assays showed the significant suppression of CRC cell proliferation (P < .01) compared with two control groups; the number of invaded cells also decreased (P < .01). These findings suggest that TXNDC9 gene may function in cancer development and may be an effective target for inhibiting the growth and metastasis of CRC cells.

引用

页码：721 / 726

页数：6

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