Relationship between chronic kidney disease without diabetes mellitus and components of frailty in community-dwelling Japanese older adults

AimTo evaluate the relationship between kidney function without diabetes and components of the frailty phenotype in community-dwelling Japanese older adults. MethodsParticipants were 8343 residents who completed baseline assessments, classified into four categories according to eGFR. Frailty status was defined using five criteria: (i) slow gait speed; (ii) muscle weakness; (iii) low physical activity; (iv) exhaustion; and (v) unintentional weight loss. ResultsAfter multivariate adjustment, participants with the lowest kidney function were at higher risk of frailty (OR 1.57, 95% CI 1.02-3.50) than those with normal kidney function. In addition, after adjustment for multiple confounders, estimated glomerular filtration rate <30 was associated with a greater risk of the individual frailty components of weight loss (OR 2.14, 95% CI 1.11-4.12), low physical activity (OR 1.35, 95% CI, 1.01-2.54) and slowness (OR 1.82, 95% CI 1.36-3.77) compared with estimated glomerular filtration rate 60. ConclusionsLower kidney function was associated with a higher risk of weight loss, low physical activity and slowness among community-dwelling Japanese older adults. Geriatr Gerontol Int 2018; 18: 286-292.