Intrathecal baclofen for progressive neurological disease in childhood: A systematic review of literature

被引：16
作者：
Bonouvrie, Laura A. [3 ]
van Schie, Petra E. M. [3 ]
Becher, Jules G. [3 ]
van Ouwerkerk, Willem J. R. [2 ]
Vermeulen, R. Jeroen [1 ]
机构：
[1] Vrije Univ Amsterdam, Med Ctr, Dept Child Neurol, NL-1007 MB Amsterdam, Netherlands
[2] Vrije Univ Amsterdam, Med Ctr, Dept Neurosurg, Amsterdam, Netherlands
[3] Vrije Univ Amsterdam, Med Ctr, Dept Rehabil Med, Amsterdam, Netherlands
来源：
EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY | 2012年 / 16卷 / 03期
关键词：
Intrathecal baclofen; Progressive neurological disease; Spasticity; HEREDITARY SPASTIC PARAPARESIS; CEREBRAL-PALSY; THERAPY; SCOLIOSIS; CHILDREN; GAIT; PARAPLEGIA; MANAGEMENT; BENEFITS; EFFICACY;
D O I：
10.1016/j.ejpn.2011.07.008
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background: Intrathecal baclofen (ITB) treatment is frequently used for individuals with severe, but non-progressive, spasticity refractory to oral treatment. However, experiences with ITB in patients with progressive neurological disorders of childhood causing spasticity are limited. Aim: To investigate whether ITB is an option in patients with progressive neurological disorders causing spasticity in childhood. Design: A systematic literature search in Embase, Pubmed and the Cochrane Library was performed. Results: We identified six eligible studies considering patients with progressive neurological disease in childhood and receiving ITB treatment. The studies included a total of seven paediatric patients and four adult patients. Improvement was reported in spasticity, spasms, pain, gait, activities of daily life and providing care. High satisfaction is described. Conclusions: ITB has beneficial effects in paediatric patients with progressive neurological disease. However, the level of evidence is limited due to the small number of available studies and due to the poor quality of these studies. (C) 2011 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：279 / 284
页数：6
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