Copper-Catalyzed Regioselective C-H Aerobic Oxidative Cycloetherification of o-Arylphenols Bearing an Additional Directing Group

被引：15
作者：
Zhao, Jiaji [1 ,2 ]
Wang, Yong [1 ,2 ]
Zhu, Qiang [1 ,2 ]
机构：
[1] Chinese Acad Sci, Guangzhou Inst Biomed, State Key Lab Resp Dis, 190 Kaiyuan Ave, Guangzhou 510530, Guangdong, Peoples R China
[2] Chinese Acad Sci, Guangzhou Inst Hlth, State Key Lab Resp Dis, Guangzhou 510530, Guangdong, Peoples R China
来源：
SYNTHESIS-STUTTGART | 2012年 / 44卷 / 10期
基金：
美国国家科学基金会;
关键词：
chelation; copper catalysis; cycloetherification; dibenzofuran; oxidative annulation; N BOND FORMATION; DIRECT ARYLATION; DIBENZOFURANS; FUNCTIONALIZATION; CYCLIZATION; CARBAZOLES; IODOANILINES; IODOPHENOLS; ACTIVATION; ATMOSPHERE;
D O I：
10.1055/s-0031-1290966
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient copper-catalyzed C-H oxidative cycloetherification of o-arylphenols containing an additional directing group under an oxygen atmosphere was developed. 2,6-Disubstituted dibenzofuran derivatives were prepared by regioselective activation of the sterically more hindered C-H bond. The presence of the extra directing group not only controls the regioselectivity, but also increases the cyclization efficiency significantly.
引用
收藏
页码：1551 / 1555
页数：5
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