Administration of AS03B-adjuvanted A(H1N1)pdm09 Vaccine in Children Aged <3 Years Enhances Antibody Response to H3 and B Viruses Following a Single Dose of Trivalent Vaccine One Year Later

被引：9
作者：
Hoschler, Katja [1 ]
Andrews, Nick J. [1 ]
Faust, Saul N. [2 ]
Finn, Adam [3 ]
Pollard, Andrew J. [4 ]
Snape, Matthew D. [4 ]
Walker, Woolf T. [2 ]
Zambon, Maria [1 ]
Miller, Elizabeth [1 ]
机构：
[1] Publ Hlth England Colindale, London, England
[2] Univ Southampton, Fac Med, Acad Unit Clin & Expt Sci, Southampton SO9 5NH, Hants, England
[3] Univ Bristol, Bristol BS8 1TH, Avon, England
[4] Univ Oxford, Dept Paediat, Oxford Vaccine Grp, Oxford OX1 2JD, England
来源：
CLINICAL INFECTIOUS DISEASES | 2014年 / 58卷 / 02期
关键词：
vaccine; influenza; childhood; oil-in-water adjuvant; cross-reactive effects; INACTIVATED INFLUENZA VACCINE; PANDEMIC VACCINE; SPLIT-VIRION; OPEN-LABEL; IMMUNOGENICITY; SAFETY; REACTOGENICITY; MULTICENTER; PERSISTENCE; EMULSION;
D O I：
10.1093/cid/cit692
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Background. We report on a follow-up clinical and serological investigation of 274 children who received seasonal influenza vaccine (trivalent inactivated vaccine [TIV]) 1 year after receipt of either AS03(B)-adjuvanted subunit or whole virus monovalent A(H1N1)pdm09 vaccine and describe the antibody responses to the H3N2 A/Perth/16/2009 and B/Brisbane/60/2008 components of TIV. Methods. Vaccine responses were analyzed using hemagglutination inhibition (HAI) assays. In children aged <3 years, previous receipt of adjuvanted vaccine resulted in higher HAI antibody responses to H3N2 and B strains compared with nonadjuvanted vaccine (fold change 16.8 vs 4.3 for H3N2 and 7.0 vs 1.6 for B). In children aged >3 years, responses to the H3 and B components of TIV were similar between vaccine groups. Sera taken before and after the pandemic vaccine were also analyzed by HAI using A/Perth/16/2009 virus. This analysis showed that 11.1% of children receiving the AS03(B)-adjuvanted vaccine but only 1.4% in the nonadjuvanted group had a 4-fold rise to A/Perth/16/2009. Conclusion. AS03(B)-adjuvanted A(H1N1)pdm09 influenza vaccine generates a cross-reactive antibody response to H3N2 in children and enhances responses to heterologous subtypes in children aged <3 years 1 year later.
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页码：181 / 187
页数：7
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