MICROWAVE-ASSISTED SYNTHESIS OF COUMARIN BASED 1,3,5-TRIAZINYL PIPERAZINES AND PIPERIDINES AND THEIR ANTIMICROBIAL ACTIVITIES

A series of 1,3,5-triazine derivatives that contain aniline, 4-hydroxycoumarin and 7-hydroxy-4-methylcoumarin and different piperazines and piperidines as substituents on the carbon atoms of the triazine ring has been synthesized by a simple and efficient synthetic protocol. Comparative studies were performed on above compounds, which were synthesized with conventional and microwave heating method. The microwave method was observed to be more beneficial as it provides an increase of yield and 90-95% reduction time. The antimicrobial activity of the compounds was tested against four bacteria (Staphylococcus aureus MTCC 96, B. subtilis MTCC 441, Escherichia coli MTCC 739, Pseudomonas aeruginosa MTCC 741) and two fungi (Aspergillus niger MTCC 282, Candida albicans MTCC 183). The preliminary in vitro evaluation studies revealed that some of the compounds have promising antimicrobial activities.