Autoantibodies against vinculin in patients with chronic inflammatory demyelinating polyneuropathy

被引：7

作者：

Beppu, Minako ^{[1
,2
]}

Sawai, Setsu ^{[2
]}

Satoh, Mamoru ^{[2
]}

Mori, Masahiro ^{[1
]}

Kazami, Takahiro ^{[2
]}

Misawa, Sonoko ^{[1
]}

Shibuya, Kazumoto ^{[1
]}

Ishibashi, Masumi ^{[2
]}

Sogawa, Kazuyuki ^{[2
]}

Kado, Sayaka ^{[3
]}

Kodera, Yoshio ^{[4
]}

Nomura, Fumio ^{[2
]}

Kuwabara, Satoshi ^{[1
]}

机构：

[1] Chiba Univ, Grad Sch Med, Dept Neurol, Chuo Ku, Chiba 2608670, Japan

[2] Chiba Univ, Grad Sch Med, Dept Mol Diag, Chuo Ku, Chiba 2608670, Japan

[3] Chiba Univ, Ctr Chem Anal, Inage Ku, Chiba 2638522, Japan

[4] Kitasato Univ, Sch Sci, Dept Phys, Minami Ku, Sagamihara, Kanagawa 2520373, Japan

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2015年 / 287卷

关键词：

Chronic inflammatory demyelinating polyneuropathy; Autoantibody; Vinculin; Epitope; GUILLAIN-BARRE-SYNDROME; PERIPHERAL NERVOUS-SYSTEM; SCHWANN-CELLS; POLYRADICULONEUROPATHY; ANTIBODIES; PROTEIN; TARGET; MYELIN; NEUROPATHIES; NEUROFASCIN;

D O I：

10.1016/j.jneuroim.2015.07.012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To identify the target molecules of chronic inflammatory demyelinating polyneuropathy (CIDP), we used proteomic-based approach in the extracted proteins from porcine cauda equina. Two of 31 CIDP patients had markedly elevated serum autoantibodies against vinculin, a cell adhesion protein. Both of the patients with anti-vinculin antibodies had similar clinical manifestation, which are compatible with those of "typical" CIDP. Immunocytochemistry showed that vinculin was stained at the myelin sheath of the sciatic nerves by serum samples. Our results suggest that vinculin is a possible immunological target molecule in a subpopulation of typical CIDP patients. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：9 / 15

页数：7

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