Double-membrane thermoresponsive hydrogels from gelatin and chondroitin sulphate with enhanced mechanical properties

被引:22
作者
Criado, M. [1 ]
Rey, J. M. [1 ]
Mijangos, C. [1 ]
Hernandez, R. [1 ]
机构
[1] CSIC, Inst Ciencia & Tecnol Polimeros, C Juan de la Cierva 3, Madrid 28006, Spain
关键词
POLYELECTROLYTE COMPLEXES; NANOPARTICLES; ALGINATE; RELEASE; GLYCOSAMINOGLYCANS; ANTIBACTERIAL; PROTEOGLYCANS; FABRICATION; COLLAGEN; DESIGN;
D O I
10.1039/c6ra25053j
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Hydrogels made of gelatin (G) and chondroitin sulphate (ChS) have been obtained by a simple method involving layer-by-layer (LbL) deposition. The procedure gives rise to double membrane hydrogels whose thickness can be modulated with pH and concentration. The resulting hydrogels present improved mechanical properties with respect to interpenetrating polymer networks and retain their thermo-responsive behaviour.
引用
收藏
页码:105821 / 105826
页数:6
相关论文
共 31 条
[1]   Polyelectrolyte complexes of poly[(2-dimethylamino) ethyl methacrylate]/chondroitin sulfate obtained at different pHs: I. Preparation, characterization, cytotoxicity and controlled release of chondroitin sulfate [J].
Bonkovoski, Leticia C. ;
Martins, Alessandro F. ;
Bellettini, Ismael C. ;
Garcia, Francielle P. ;
Nakamura, Celso V. ;
Rubira, Adley F. ;
Muniz, Edvani C. .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2014, 477 (1-2) :197-207
[2]   Molecular Interactions Driving the Layer-by-Layer Assembly of Multilayers [J].
Borges, Joao ;
Mano, Joao F. .
CHEMICAL REVIEWS, 2014, 114 (18) :8883-8942
[3]   An integrated device for magnetically-driven drug release and in situ quantitative measurements: Design, fabrication and testing [J].
Bruvera, I. J. ;
Hernandez, R. ;
Mijangos, C. ;
Goya, G. F. .
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, 2015, 377 :446-451
[4]   Gelatin-chondroitin-hyaluronan tri-copolymer scaffold for cartilage tissue engineering [J].
Chang, CH ;
Liu, HC ;
Lin, CC ;
Chou, CH ;
Lin, FH .
BIOMATERIALS, 2003, 24 (26) :4853-4858
[5]   Extremely strong and tough hydrogels as prospective candidates for tissue repair - A review [J].
Costa, Ana M. S. ;
Mano, Joao F. .
EUROPEAN POLYMER JOURNAL, 2015, 72 :344-364
[6]   Structural Analysis of Glycosaminoglycans and Proteoglycans by Means of Raman Microspectrometry [J].
Ellis, Richard ;
Green, Ellen ;
Winlove, C. Peter .
CONNECTIVE TISSUE RESEARCH, 2009, 50 (01) :29-36
[7]   Hydrogel based on an alginate-Ca2+/chondroitin sulfate matrix as a potential colon-specific drug delivery system [J].
Fajardo, Andre R. ;
Silva, Mateus B. ;
Lopes, Lais C. ;
Piai, Juliana F. ;
Rubira, Adley F. ;
Muniz, Edvani C. .
RSC ADVANCES, 2012, 2 (29) :11095-11103
[8]   Polyelectrolyte complexes based on pectin-NH2 and chondroitin sulfate [J].
Fajardo, Andre R. ;
Lopes, Lais C. ;
Pereira, Antonio G. B. ;
Rubira, Adley F. ;
Muniz, Edvani C. .
CARBOHYDRATE POLYMERS, 2012, 87 (03) :1950-1955
[9]   RAMAN-SCATTERING OF COLLAGEN, GELATIN, AND ELASTIN [J].
FRUSHOUR, BG ;
KOENIG, JL .
BIOPOLYMERS, 1975, 14 (02) :379-391
[10]   Effect of maleimide-functionalized gold nanoparticles on hybrid biohydrogels properties [J].
Garcia-Astrain, C. ;
Ahmed, I. ;
Kendziora, D. ;
Guaresti, O. ;
Eceiza, A. ;
Fruk, L. ;
Corcuera, M. A. ;
Gabilondo, N. .
RSC ADVANCES, 2015, 5 (62) :50268-50277