Icariin Exerts Protective Effect Against Myocardial Ischemia/Reperfusion Injury in Rats

被引：32
|
作者：
Meng, Xing [1 ]
Pei, Hui [1 ]
Lan, Chao [1 ]
机构：
[1] Zhengzhou Univ, Dept Emergency, Affiliated Hosp 1, Zhengzhou 450052, Henan, Peoples R China
来源：
CELL BIOCHEMISTRY AND BIOPHYSICS | 2015年 / 73卷 / 01期
关键词：
Icariin; Myocardial ischemia/reperfusion; PI3K/Akt; ISCHEMIA-REPERFUSION INJURY; HEART-FAILURE; PATHWAY; APOPTOSIS; INTERLEUKIN-10; CELLS;
D O I：
10.1007/s12013-015-0669-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Icariin, a plant-derived flavonoid, has multiple beneficial actions on the cardiovascular system. The current study investigated whether icariin postconditioning has any protective effects on myocardial ischemia/reperfusion (I/R) injury in vivo and its potential cardioprotective mechanisms. In in vivo rat model of myocardial ischemia/reperfusion, we found that postconditioning with icariin significantly reduced myocardial infarct size, serum level of TNF-alpha and IL-10, TNF-alpha and IL-10 expression, and apoptosis. Moreover, our results showed that icariin postconditioning exerts cardioprotective effect against myocardial I/R injury through activating PI3K/Akt using PI3K/Akt inhibitor LY294002.
引用
收藏
页码：229 / 235
页数：7
相关论文
共 50 条
  • [11] PROTECTIVE EFFECT OF CAFFEINE ADMINISTRATION ON MYOCARDIAL ISCHEMIA/REPERFUSION INJURY IN RATS
    Li, Xu-Yong
    Xu, Lin
    Lin, Guo-Sheng
    Li, Xiao-Yan
    Jiang, Xue-Jun
    Wang, Tao
    Lue, Jing-Jun
    Zeng, Bin
    SHOCK, 2011, 36 (03): : 289 - 294
  • [12] Protective effect of morin on myocardial ischemia-reperfusion injury in rats
    Liu, Shuang
    Wu, Nan
    Miao, Jiaxin
    Huang, Zijun
    Li, Xuying
    Jia, Pengyu
    Guo, Yuxuan
    Jia, Dalin
    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2018, 42 (03) : 1379 - 1390
  • [13] Protective effect of hydrogen sulfide on myocardial Ischemia reperfusion injury in rats
    Chen, Xiehui
    Li, Peng
    Huang, Xiaoping
    CARDIOLOGY, 2013, 126 : 31 - 31
  • [14] Protective effect of pioglitazone on myocardial Ischemia-reperfusion injury in rats
    Ye, P.
    Cao, Z. L.
    Long, C. L.
    Chen, K.
    ATHEROSCLEROSIS SUPPLEMENTS, 2006, 7 (03) : 372 - 372
  • [15] The protective effect of polyphyllin I on myocardial ischemia/reperfusion injury in rats
    Huang, Ruizhen
    Shu, Jia
    Dai, Xiaoqin
    Liu, Yanru
    Yu, Fang
    Shi, Gang
    ANNALS OF TRANSLATIONAL MEDICINE, 2020, 8 (10)
  • [16] Protective effect of picroside II on myocardial ischemia reperfusion injury in rats
    Wu, Nan
    Li, Wenna
    Shu, Wenqi
    Jia, Dalin
    DRUG DESIGN DEVELOPMENT AND THERAPY, 2014, 8 : 545 - 554
  • [17] THE PROTECTIVE EFFECT OF SASANQUASAPONIN ON MYOCARDIAL ISCHEMIA-REPERFUSION INJURY IN RATS
    Xiao, H.
    Li, X.
    Chen, Y. P.
    Chen, L. Y.
    Zeng, R. Y.
    BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2017, 121 : 23 - 23
  • [18] Protective effects of xanthones against myocardial ischemia-reperfusion injury in rats
    Jiang, DJ
    Tan, GS
    Ye, F
    Du, YH
    Xu, KP
    Li, YJ
    ACTA PHARMACOLOGICA SINICA, 2003, 24 (02) : 175 - 180
  • [19] PROTECTIVE EFFECTS OF DIOSGENIN AGAINST MYOCARDIAL INJURY INDUCED BY ISCHEMIA AND REPERFUSION IN RATS
    Wang, Tong
    Chen, Jianping
    Huang, Hui
    Shen, Jiangang
    Yang, Depo
    Wang, Dongmei
    CRITICAL CARE MEDICINE, 2009, 37 (12) : A411 - A411
  • [20] Protective effects of vitamin E against myocardial ischemia/reperfusion injury in rats
    Saleh, Nermine K.
    Saleh, Hanan A.
    SAUDI MEDICAL JOURNAL, 2010, 31 (02) : 142 - 147
12345