Icariin Exerts Protective Effect Against Myocardial Ischemia/Reperfusion Injury in Rats

被引：32
|
作者：
Meng, Xing [1 ]
Pei, Hui [1 ]
Lan, Chao [1 ]
机构：
[1] Zhengzhou Univ, Dept Emergency, Affiliated Hosp 1, Zhengzhou 450052, Henan, Peoples R China
来源：
CELL BIOCHEMISTRY AND BIOPHYSICS | 2015年 / 73卷 / 01期
关键词：
Icariin; Myocardial ischemia/reperfusion; PI3K/Akt; ISCHEMIA-REPERFUSION INJURY; HEART-FAILURE; PATHWAY; APOPTOSIS; INTERLEUKIN-10; CELLS;
D O I：
10.1007/s12013-015-0669-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Icariin, a plant-derived flavonoid, has multiple beneficial actions on the cardiovascular system. The current study investigated whether icariin postconditioning has any protective effects on myocardial ischemia/reperfusion (I/R) injury in vivo and its potential cardioprotective mechanisms. In in vivo rat model of myocardial ischemia/reperfusion, we found that postconditioning with icariin significantly reduced myocardial infarct size, serum level of TNF-alpha and IL-10, TNF-alpha and IL-10 expression, and apoptosis. Moreover, our results showed that icariin postconditioning exerts cardioprotective effect against myocardial I/R injury through activating PI3K/Akt using PI3K/Akt inhibitor LY294002.
引用
收藏
页码：229 / 235
页数：7
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