Differential expression of two tumor necrosis factor genes in rainbow trout, Oncorhynchus mykiss

被引：139
|
作者：
Zou, J
Wang, T
Hirono, I
Aoki, T
Inagawa, H
Honda, T
Soma, GI
Ototake, M
Nakanishi, T
Ellis, AE
Secombes, CJ
机构：
[1] Univ Aberdeen, Dept Zool, Aberdeen AB24 2TZ, Scotland
[2] Tokyo Univ Fisheries, Dept Aquat Biosci, Tokyo 108, Japan
[3] Tokushima Bunri Univ, Inst Hlth Sci, Yamashiro, Tokushima 7708514, Japan
[4] Natl Res Inst Aquaculture, Immunol Sect, Tamaki, Mie 5190423, Japan
[5] Nihon Univ, Dept Vet Med, Kanagawa 2528510, Japan
[6] FRS Marine Lab, Aberdeen AB11 9DB, Scotland
来源：
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY | 2002年 / 26卷 / 02期
关键词：
TNF alpha; rainbow trout; gene organisation; differential expression;
D O I：
10.1016/S0145-305X(01)00058-1
中图分类号：
S9 [水产、渔业];
学科分类号：
0908 ;
摘要：
A second TNF gene (TNF2) has been cloned and sequenced in rainbow trout. In common with the first TNF gene isolated (TNF1), this gene is more TNFalpha-like than TNFbeta-like. The full length cDNA is 1519 bp, containing a 765 bp open reading frame. The gene has four exons, of 380,49,60 and 1030 bp, respectively. Analysis of the 5' flanking regions of TNF1 and TNF2 reveals several interesting differences in identified transcriptional regulatory elements, with a CATAAA box present 26 bp upstream of the transcription start in both genes. Expression analysis in LPS stimulated macrophages has shown a much stronger expression of TNF2 relative to TNF1, with expression being detected earlier and lasting longer. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：161 / 172
页数：12
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