Natural origin hydroxyapatite scaffold as potential bone tissue engineering substitute

被引:110
作者
Mondal, Sudip [1 ]
Pal, Umapada [1 ]
Dey, Apurba [2 ]
机构
[1] Benemerita Univ Autonoma Puebla, Inst Fis, Apdo Postal J-45, Puebla 72570, Mexico
[2] Natl Inst Technol Durgapur, Dept Biotechnol, MG Ave, Burdwan 713209, W Bengal, India
关键词
Fish scale; Hydroxyapatite; Scaffold; Bone tissue; CERAMIC SCAFFOLDS; BIOACTIVE GLASS; REPLACEMENT; APATITES;
D O I
10.1016/j.ceramint.2016.08.165
中图分类号
TQ174 [陶瓷工业]; TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
Fish scales derived natural hydroxyapatite (FS-HAp) scaffolds were prepared through solvent casting technique, which could mimic the structure of cortical and cancellous bone tissues of body system. The hydroxyapatite (HAp) biomaterial was synthesized by thermal decomposition of chemically treated fish scales. Fabricated scaffolds were characterized through morphological analysis, volumetric shrinkage, mechanical tests, and in vitro, in vivo biological studies. The projected scaffolds successfully mimic the cancellous/cortical bone system in terms of structure, porosity, mechanical strength, and exhibit excellent bioactive behavior. The FS-HAp scaffolds manifest good mechanical behaviors with Vickers Hardness (HV) of similar to 0.78 GPa, 0.52 GPa compressive stress, 190 MPa tensile stress and similar to 35% porosity on sintering at 1200 degrees C. In vitro and in vivo studies suggest these nontoxic HAp scaffolds graft with osteo-conductive support, facilitating new cell growth on the developed scaffold surface. The graded grafts have a great potential for application as traumatized tissue augmentation substitute, and ideal for load bearing bone applications. (C) 2016 Elsevier Ltd and Techna Group S.r.l. All rights reserved.
引用
收藏
页码:18338 / 18346
页数:9
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