Distinguishing Urothelial Carcinoma in the Upper Urinary Tract from Benign Diseases with Hematuria Using FISH

被引：9

作者：

Wang, Jiandong ^{[1
]}

Wu, Jinrong ^{[1
]}

Peng, Libo ^{[1
]}

Tu, Pin ^{[1
]}

Li, Wanchun ^{[1
]}

Liu, Leilei ^{[1
]}

Cheng, Wen ^{[2
]}

Wang, Xuan ^{[1
]}

Zhou, Shuigen ^{[2
]}

Shi, Shanshan ^{[1
]}

Ma, Henghui ^{[1
]}

Lu, Guangming ^{[3
]}

Zhou, Xiaojun ^{[1
]}

机构：

[1] Nanjing Univ, Sch Med, Nanjing Jinling Hosp, Dept Pathol, Nanjing 210002, Jiangsu, Peoples R China

[2] Nanjing Univ, Sch Med, Nanjing Jinling Hosp, Dept Urol, Nanjing 210002, Jiangsu, Peoples R China

[3] Nanjing Univ, Sch Med, Nanjing Jinling Hosp, Dept Radiol, Nanjing 210002, Jiangsu, Peoples R China

来源：

ACTA CYTOLOGICA | 2012年 / 56卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Fluorescence in situ hybridization; Hematuria; Upper urinary tract; Urothelial carcinoma; IN-SITU HYBRIDIZATION; BLADDER-CANCER; DIAGNOSIS; CYTOLOGY; SURVEILLANCE; MULTITARGET; UTILITY; CELLS;

D O I：

10.1159/000341622

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Objective: The aims of this study were to evaluate the clinical utility of a fluorescence in situ hybridization (FISH) assay as a non-invasive molecular test to distinguish urothelial carcinoma (UC) in the upper urinary tract (UUT) from benign lesions presenting with hematuria. Study Design: The chromosomal abnormalities of chromosomes 3, 7, 17 and 9 (p16) in hematuria specimens from 34 patients with UUT-UC and 33 patients with benign disorders were detected using a set of fluorescently labeled DNA probes. The abnormalities of the chromosomes were determined and analyzed between UUT-UC and benign disorders. Results: Chromosomal abnormalities were detected in 25 of 34 (73.5%) patients with UUT-UC and in 2 of 33 (6.1%) patients with benign disorders (p < 0.001). Conclusions: FISH of chromosomes 3, 7, 9 and 17 performed on exfoliated cells from voided urine specimens may serve as a non-invasive tool to distinguish UUT-UC from benign disorders presenting with hematuria. Copyright (C) 2012 S. Karger AG, Basel

引用

页码：533 / 538

页数：6

共 26 条

[1]

BIAN YL, 1995, ACTA CYTOL, V39, P733

[2]

Bubendorf L, 2012, ACTA CYTOL, V55, P113

[3] Fluorescence in situ hybridization in the diagnosis of urothelial carcinoma [J].